Question

Asked 4th Nov, 2014

Monash University (Australia)

If a baby is born asphyxic with low HR and BP and requires chest compressions, is it systemically maximally vasodialted or vasoconstricted?

If a baby is born asphyxic with low HR and BP and requires chest compression. Is it systemically, maximally vasodialted or vasoconstricted?

Neonatal Intensive Care

Richard Sindelar

Uppsala University

During a transient period I would say the infant is vasoconstricted peripherally and to some vital organs such as the bowel, the kidneys and the liver, because of the effort to redistribute circulation to the vital organs i.e. the heart and the brain, why it's so difficult to conclude the severity of brain damage from the observational parameters of colour, HR, breathing (APGAR) only, in these instances. The combination of both respiratory and metabolic acidosis, gives probably a vasoconstriction in itself. The observation of low BP is probablhy more the effect of a bad pump than a vasodilation - but also the difficulty to measure BP manually in these infants (not defined from the question). There is probably a risk of heart congestion trying to correct the supposed vasodilation with volume, which is done in many of these situations, usually by clinicians suspecting either volume loss due to bleeding or a supposed vasodilation/peripheral liquid loss. Also, many of these infants have a non-intentional (?) hypothermia during the resuscitation, further increasing peripheral vasoresistance i.e. vasoconstriction. When hypothermia is initiated as treatment, the BP is usually observed being increased with concomitant low HR.

Cite

Kathryn Browning Carmo

Sydney Children's Hospitals Network

These babies are white with presumed vasoconstriction. They become pale pink with recovery of circulation. They are not hypovolaemic so unless vasoconstircted they should be pink. Why are you asking?

Cite

Volodymyr Naumchuk

Ternopil Volodymyr Hnatiuk National Pedagogical University

Parisa Ziarati

Formerly Academic member in Pharmaceutical Faculty & honorary researcher in

Arvind Singh

Banaras Hindu University

Ca Dr. Gaurav Bhambri

University of Houston

Yehya A. Salih

University of Basrah

Interpreting a positively correlated oxy- and deoxy- fNIRS signal patterns (Other than the short time period artifacts)?

Question

4 answers

Asked 25th Dec, 2017

John Sunwoo

How do you explain when the fNIRS measurements of both the oxy- and deoxy- hemoglobin concentration changes are in the same direction? Is that simply because of the vasodilation without an increase in the flow? Is this even possible? This is depicted in Q2 and Q3 in the figure I created (below). I just put down some guesses based on the assumption that the oxy pattern will be mostly influenced by the scalp blood (vasodilation or vasoconstriction), while the de-oxy content will represent more of the neural activity. But thinking more carefully, I am not sure if these conditions are physiologic. I think I also want to explain this assuming two cases of 1) systemic influences are already filtered out and 2) both systemic and neuronal activities are present in the fNIRS signal.. And the time scale that I am interested in is about 10~50seconds of oxy and deoxy changes.

Any papers or other contacts are appreciated.

What is the best scale for investigation of moral distress in neonatal intensive care nurses?

Question

2 answers

Asked 31st Aug, 2014

Hanie Rahmian

I would be thankful, if you also recommend any scales which can be helpful in this regard.

How do you measure a premature infant's trans epidermal water loss (TEWL)?

Question

4 answers

Asked 27th May, 2015

James Marceau

Extremely Premature infant's can lose up to 75gm H20/m2/hr and to overcome this they are nursed in high levels of incubator humidity. Does anyone know what device is appropriate to measure (Trans epidermal water loss) TEWL inside an incubator in humidity?

What is the role of surfactant in meconium aspiration syndrome?

Question

8 answers

Asked 26th Dec, 2014

Deleted profile

What is the evidence?

How can high protein needs be met in the neonatal intensive care unit? evidence Any evidence for the use of beneprotein?

Question

4 answers

Asked 12th Jul, 2015

Eman Faroukh

Is there an evidence for use of beneprotein in the NICU? I only found institutes using it in their studies but I need an article stating the long term effect of beneproteins

How to do calibration work for the DEM simulation of single-grain compression/crushing of rock?

Question

1 answer

Asked 5th Apr, 2018

Lie Kong

Many rocks have comparatively large rock grains (from orders of mm to even cm). Assuming that we have simulated the crushing behaviour of a single grain based on discrete element method(DEM), how can we conduct the calibration work.

Cucumber plants have short internodes and curly leaves, cracked fruits, what is the reason?

Question

4 answers

Asked 24th Mar, 2018

Alex Ignatov

There is a strong deformation of plant tops, leaves, fruits crack along and filled with smelly liquid. The cross-and longitudinal sections free of any symptoms of systemic infection. More than 1000 diseased plants were found per hectare.

What is the approximately factor used to convert the compression strength of concrete by using cube to its value by using cylinder?

Question

21 answers

Asked 9th Jun, 2018

Zaid Abdul Zahra Mahdi

concrete samples to compression tests

Does Al 1100 H14 behave differently in tension and compression?

Question

3 answers

Asked 28th Jun, 2018

Sumit Gundyal

I am trying to correlate the experimental and modeling results of micro-indentation. The indent shapes are not matching because the amount of springback and material rise the model is predicting is different than that from the experiment. I tried changing the BCs, refining the mesh in the region of indentation. I didn't experiment with the contact behavior yet. But,these solutions didn't help. I am guessing the differences are due to improper material definition (using Abaqus for modeling). I am using tensile test data for the same. I wanted to know if Al 1100 H14 behaves differently in compression. If yes, how to incorporate that in Abaqus material definition?

Clinical aspects of induced hypothermia in full term neonates with perinatal asphyxia

Article

Feb 2009

Moderate hypothermia is a novel neuroprotective therapy for full term neonates with severe perinatal asphyxia. Although the therapy appears to be safe, admission to a level III neonatal intensive care unit of these patients is justified. Potential complications include hypotension, tube obstruction due to sticky secretions, severe bradycardia, and...

Cerebral vasoconstriction occurs prior to systemic vasodilatation in neurocardiogenic syncope

Article