University of Eldoret
Question
Asked 21st Jul, 2021
Can we use the adjusted odds ratio for sample size calculation? what is the recommendation please?
I am to calculate sample size for a case control study and I am not sure whether to use the crude odds ratio or the adjusted odds ratio of other studies to estimate my sample size
Most recent answer
Kindly look at this paper.
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Popular answers (1)
SEGi University College
- Kindu Yinges Define rates of participants for each group of outcome ,the minimum clinical significant difference , define the expected prevalence of exposure and define your significance level (usually p<0.05) and the power.
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All Answers (6)
SEGi University College
- Kindu Yinges Define rates of participants for each group of outcome ,the minimum clinical significant difference , define the expected prevalence of exposure and define your significance level (usually p<0.05) and the power.
16 Recommendations
Mississippi State University (Emeritus)
Hello Kindu,
I agree with Pradeep Paraman 's suggestion that you should identify the smallest degree of difference that is clinically noteworthy and use that as an estimate your effect size (regardless of the metric you use, odds ratio or something else). This might be a value that you can derive from polling domain experts, or which could be justified by an economic analysis. Do recognize that this value might not correspond to what ES (OR) values are reported in existing, related studies (whether crude or adjusted).
If you must go with mirroring published values, I'd suggest opting for adjusted OR values, as these are generally (but not universally) lower than crude OR values, especially if you intend to include other "control" variables in your analysis.
Good luck with your work.
5 Recommendations
Babeş-Bolyai University
Hello,
Adj-OR. It is more conservative and safe in a multivariate environment if you will reuse the same variables. If not, doesn't really matter, or go for another method.
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