Download a complimentary poster listing the major phenotypes of the immunodeficient range of Charles River mice and rats bred in North America. This poster includes information on model features, degree of immunodeficiency, and gene functions.

Download a complimentary poster listing the major phonotypes of the immunodeficient range of Charles River mice and rats bred in Europe. This poster includes information on model features, degree of immunodeficiency, and gene functions.

Our NCG Plus Portfolio will broaden the scope of humanized mouse research by featuring a comprehensive and versatile selection of models that
Express human immune receptors.
Support stable engraftment of additional immune compartments.
Allow for easier humanization and in vivo assessment of study parameters.
Available this summer are:
NCG-X: allows better engraftment, and expansion of red blood cell compartment & doesn't require irradiation to become humanized.
NCG-M: expresses three human cytokines (IL3, GM-CSF [CSF2], and SCF [KITLG]) and is also an applicable model for acute myeloid leukemia (AML) research.
Additional strains will be introduced throughout the next two years. Sign up to be the first to know about new introductions or to receive pre-order information.

Download a copy of the SRG Rat Overview which outlines the evolution and application of this highly immunodeficient rat model in oncology research.
In addition, to flow cytometry analysis on immune subpopulations, this document also provides tumor growth kinetics on 20 different human tumor cell lines from various organs that include the lung, breast, prostate, and others.

Avoid painful ear and tail biopsies: get to know the benefits and applications of using non-invasive oral swab samples to genotype your mice!
Our latest poster explains how this sampling method was adapted by our team of experts into our optimized automated genotyping workflow for conventional PCR, real-time qPCR, and endpoint analysis.
You can contribute to animal welfare beyond simply meeting the regulatory requirements. Download the poster to discover how.

The health of laboratory animals is vital to their suitability for research; therefore, an animal health quality control program is important to any research facility. This book highlights infection surveillance for rodent populations, provides a brief overview of agents to consider as part of a program and offers recommendations for the selection of assays.

This book provides information on managing mouse and rat colonies, colony management from a genetics and reproductive standpoint, and guidance for troubleshooting colony performance.

As the numbers of genetically modified models increase, the implementation of a cryopreservation program and the subsequent biobanking of the material are important steps toward conserving and protecting these models for future advancement of biomedical science.

This guide contains practical clinical information for anyone working with laboratory rodents and rabbits, including veterinarians, veterinary technicians, and research personnel.

Covering species-typical behavior as well as abnormal/malfunctional behavior and stereotypes observed in mice, rats, hamsters, and gerbils, this resource provides information to help implement or enhance an existing behavioral husbandry and enrichment program.

From breeding practices to behavior and enrichment programs, the Charles River Guidebook Series gives laboratory animal professionals insight into running an effective and humane vivarium.

In recent years, with the rise of cell and gene therapies, adeno-associated viruses have been identified as the most important delivery vector in therapeutic development.
When working with AAVs in animal models, it's critical to know how prevalent neutralizing antibodies are to increase the efficacy of an adeno-associated virus gene therapy.
Take advantage of our sero-specific neutralizing antibody testing and screening solutions and help maximize the delivery of your gene therapy candidate.

Many researchers around the globe house and manage their genetically engineered mice and rats at one of our facilities. In order to quickly demonstrate our service offering and the benefits it provides, we've created an interactive digital tour of our off-site colony management services.
Learn the benefits of outsourcing the breeding of your genetically engineered rodents as we review how to:
Obtain a higher level of control & improve data management
Overcome challenges of space constraints/facility moves/refurbishments
Address concerns regarding health status and biosecurity
Focus time on research, not managing a rodent colony

The Charles River hACE2-NCG mouse is a novel, engineered hACE2-modified mouse developed specifically for COVID-19 research. The hACE2-NCG model is developed on the NCG triple-immunodeficient background containing hACE2 (Angiotensin Converting Enzyme 2), the receptor used by SARS-CoV-2 to enter cells.
hACE-2NCG is humanizable
The hACE-2NCG mouse was designed to support critical translational research intended to mimic various human immune responses following exposure to SARS-CoV-2. Through the engraftment of human cells, part of the immune system can be reconstituted prior to SARS-CoV-2 infection.
Available only in North America region

Our video series provides a virtual platform for researchers like you to discuss your work and engage with the broader scientific community. We are committed to continuously providing value to this community and we hope this series will promote collaboration among labs across the globe.
These videos are highly conversational in nature and aim to spur innovative ideas and solutions.
Video 1: The Role of Rodent Models in Assessing the Impact of Methamphetamine-Induced Dopamine Neurotoxicity
Video 2: Sleep and Cardiovascular Health: The Role of Rat Models
SPOTLIGHT YOUR WORK. Share your disruptive research with a wide range of researchers and connect with key opinion leaders. Promote your work by linking to your video on your personal and professional sites, LinkedIn, and other social media accounts. Participate from the comfort of your home, lab, or office.

As the numbers of genetically modified models increase, the continuous breeding and culling and other costly labor-intense procedures are decreased with the application of either embryo or spermatozoa cryopreservation.
The implementation of a cryopreservation program and the subsequent biobanking of the material are important steps toward conserving and protecting these models for future advancement of biomedical science.
Download this free guidebook to learn about:
1. Inbred and F1 Hybrid Strains
2. Outbred Stocks
3. Creating Genetically Engineered Models
4. Rederivation
5. Cyropreservation

Selecting the most appropriate rodent model is critical to the success and reproducibility of your research, and Charles River's Animal Model Evaluation Program allows you to assess the quality and compatibility of our models before making a financial commitment.
Over 1000 researchers globally have already benefited from the program, as it provides high-quality, genetically standardised models suitable for all major therapeutic areas, at no-cost.

Learn about applications, level of immunodeficiency, model features, and gene functions.

Selecting the most appropriate rodent model is critical to the success and reproducibility of your research, and Charles River's Animal Model Evaluation Program allows you to assess the quality and compatibility of our models before making a financial commitment.
Over 1000 researchers globally have already benefited from the program, as it provides high-quality, genetically standardised models suitable for all major therapeutic areas, at no-cost.

The quest to develop increasingly immunodeficient mice has been a decades-long journey with the aim of establishing the most permissive platform for the engraftment of human cells and tissues (Shultz et al., 2007).
In the course of this white paper, we will address the components of the strain that confer immunodeficiency, genetic integrity of NSG® mice, and focus on key cancer applications including PDX modelling and humanised mice for immuno-oncology research. We will also highlight many of the NSG variant strains that have come to exist in response to refined research needs.

Learn about applications, level of immunodeficiency, model features, and gene functions.

Selecting the most appropriate rodent model is critical to the success and reproducibility of your research, and Charles River's Animal Model Evaluation Program allows you to assess the quality and compatibility of our models before making a financial commitment.
Over 1000 researchers globally have already benefited from the program, as it provides high-quality, genetically standardised models suitable for all major therapeutic areas, at no-cost.
If you have any questions regarding model selection, or how the program works, Charles River's team will also be happy to assist you with this.

Learn about applications, level of immunodeficiency, model features, and gene functions.

The COVID-19 crisis has paused research and halted countless studies at academic institutions in North America. While the challenges are great, so is the need to push discovery forward. Now is the time to prepare for the next phase of your work. We are here with discounted offerings, guidance and tools to support and accelerate your research in the new normal. Take advantage of what the program can offer you and browse our educational resources of Guidebooks, Posters, Webinars and our Short Course.