Figure 2 - available via license: Creative Commons Attribution-NonCommercial 4.0 International
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Intestinal stem cell injury by ischemia-reperfusion injury. A: Immunofluorescence staining with caspase-3 (green) revealed mucosal injury at the epithelial layer closed to the tip of the villi in the ischemia group; B: Extensive apoptosis was identified at the crypt base and the whole epithelial layer in the reperfusion group; C: Apoptosis at the crypt base was limited in the hydrogen group. Scale bar: 100 μm.
Source publication
Background:
Patients with mesenteric ischemia frequently suffer from bowel necrosis even after revascularization. Hydrogen gas has showed promising effects for ischemia-reperfusion injury by reducing reactive oxygen species in various animal and clinical studies. We examined intestinal tissue injury by ischemia and reperfusion under continuous ini...
Contexts in source publication
Context 1
... analyses with caspase-3 antibodies revealed that the intestinal mucosa of the ischemia group was mainly injured at the epithelial layer closed to the tip of the villi (Figure 2A). In the reperfusion group, apoptosis was extensively identified at the crypt base, where intestinal stem cells exist [23,24], in addition to injuries at the whole epithelial layer ( Figure 2B). ...
Context 2
... analyses with caspase-3 antibodies revealed that the intestinal mucosa of the ischemia group was mainly injured at the epithelial layer closed to the tip of the villi (Figure 2A). In the reperfusion group, apoptosis was extensively identified at the crypt base, where intestinal stem cells exist [23,24], in addition to injuries at the whole epithelial layer ( Figure 2B). Apoptosis at the crypt base was limited in the hydrogen group ( Figure 2C), whereas epithelial injury was observed at the villi with a half side of the digestive tract. ...
Context 3
... the reperfusion group, apoptosis was extensively identified at the crypt base, where intestinal stem cells exist [23,24], in addition to injuries at the whole epithelial layer ( Figure 2B). Apoptosis at the crypt base was limited in the hydrogen group ( Figure 2C), whereas epithelial injury was observed at the villi with a half side of the digestive tract. ...
