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karyotype of the male with 46, XY, 9qh+ & del 3. Showed a male karyotype with 46, XY, 9qh+ (increased heterochromatin on chromosome 9) and delete in chromosome 3. (X100) by G-banding
Source publication
T he main objective of this research study the parental chromosomal abnormalities to recurrent spontaneous abortion Parental chromosomal rearrangements are account for more than 50% of RSA. So, it became necessary in this study to determine whether chromosomal factor is involved in RSA in Iraqi population. Related to that reason, blood samples from...
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Citations
... Even so the intensity of grief reaches its peak if it happens repeatedly as in the case of recurrent miscarriages. 1 Fetal development is multifarious process which requires equilibrium of all hormonal environmental and genetic factors, abnormality in either factor can lead in the abnormal development of embryo or fetal loss. Spontaneous miscarriage is actually nature's quality control for selecting genetically normal offspring. ...
... Additionally ps+ on chromosome 15 with RSM is more commonly reported in male carriers however, in the recent data equal number of chromosome 15 heteromorphism were found in both genders. 1,12,15 A male carrier of Robertsonian translocation (chromosome 14;21) was also reported, this couple had suffered with seven recurrent miscarriages. Some of the researchers suggested female carrier of Robertsonian translocation are more prone to have RSM though our finding disclose the importance of Robertsonian translocation in male carrier. ...
Background & objective:
Spontaneous pregnancy loss has always been the frustrating experience for the couples and concern clinician. Chromosomal abnormality in either of the parent is considered to be the one of the leading cause of recurrent spontaneous miscarriages. This study was designed to evaluate the possible chromosomal etiology of miscarriage and the subsequent intimacy of maternal or paternal genetic abnormality.
Methods:
This case-control study was conducted between January 2016 and October 2016 at a tertiary care hospital in Karachi. A total of thirty-two couples were selected who had suffered with recurrent spontaneous miscarriages (RSM). Using conventional cytogenetic technique karyotyping was performed on all of the subjects. For the control twenty couples were also selected with no history of pregnancy loss. All the karyotypes were recorded on the standard method. Data was analyzed through SPSS version 22.
Results:
Among thirty-two cases nine cases were found to have abnormal karyotype. In which sex chromosomal trisomy=02 (46,XY/47,XXY), marker chromosome=01 (47,XX,+mar), Robertsonian translocation=01 (45,XY,der,(14:21),(q10;q10)), reciprocal translocation=01 (46,XX,t(11;22)(q23;q11.2)), inversion=02 (46,XX,inv(9)(p11q13)) and minor structural abnormalities=02 (46,XX,15PS+) were found. Approximately equal ratio with 1:1.25 was observed among male and female carrier respectively. Non-significant difference was found between the ages of both carriers (p=0.34). Though a significant different value was calculated in the case of number of miscarriage (p=0.004*). Moreover, no significant association was found among spontaneous miscarriage (SM) and recurrent spontaneous miscarriage (RSM) with respect to maternal age (p= 0.157).
Conclusion:
In the recent study possible chromosomal abnormalities suggested the evaluation of the patient with the history of recurrent spontaneous miscarriage must include conventional cytogenetic. Moreover, probe development and extended investigation can ease the prognosis among pregnancy related complication.
