Figure - uploaded by Abhijit Sukul
Content may be subject to copyright.
Source publication
This dissertation aimed to compare the antihyperlipidemic effects of methanolic extract of Zingiber officinale, Momordica charantia, Trigonella foenum-graecum, Dillenia indica and Tamarindus indica in hyperlipidemic animal models. Atorvastatin was used as standard drug. The crude extract (100 mg/kg) of these significantly prevented the increase in...
Similar publications
High-density lipoproteins (HDL) have multiple pleiotropic effects against arteriosclerosis. Most are independent of the cholesterol mass within HDL particles. Yet, HDL-Cholesterol (C) remains a biomarker to assess cardiovascular risk. While the epidemiological association between HDL-C and cardiovascular risk is strong, graded and coherent across p...
Familial hypercholesterolemia (FH) is the most common autosomal dominant monogenic disorder and the most severe type of genetic dyslipidemias. Although elevated plasma levels of low-density lipoprotein cholesterol (LDL-C) are the hallmark of FH, also other lipid and lipoprotein subspecies are changed in these patients. In this regard, plasma concen...
Citations
... Artemia salina Leach (brine shrimp eggs) collected from pet shops was kept properly under controlled temperature and was used as the test organism. 16 Ten (n = 10) living shrimps were added to each of the test tubes containing 5 ml of simulated sea water. ...
... Statistical analyses were done by using the Statistical Package for Social Science (SPSS) version 16.0 software, and statistical differences between groups were analyzed by one-way analysis of variance ANOVA followed by Dunnett's t-tests. 16 Data's were presented as means ± SEM of three parallel measurements and differences were considered significant at p < 0.05. ...
... Artemia salina Leach (brine shrimp eggs) collected from pet shops was kept properly under controlled temperature and was used as the test organism. 16 Ten (n = 10) living shrimps were added to each of the test tubes containing 5 ml of simulated sea water. ...
... Statistical analyses were done by using the Statistical Package for Social Science (SPSS) version 16.0 software, and statistical differences between groups were analyzed by one-way analysis of variance ANOVA followed by Dunnett's t-tests. 16 Data's were presented as means ± SEM of three parallel measurements and differences were considered significant at p < 0.05. ...
Objective: The inquisitive objective of the study was to observe the antimicrobial, cytotoxicity, and antioxidant activities of some newly synthesized metal complexes of tolfenamic acid.
Methods: While antimicrobial activity was studied by disk diffusion method, cytotoxicity was studied by performing brine shrimp lethality bioassay. Moreover, DPPH radical scavenging potential was observed to determine the antioxidant property of the complexes.
Results: From the disk diffusion antimicrobial screening of tolfenamic acid and its metal complexes, it was found out that considerable antimicrobial activity in terms of zone of inhibition against the tested organisms had been demonstrated by Cu and Zn complex of tolfenamic acid. In addition, the brine shrimp lethality bioassay corroborated that tolfenamic acid and Cu, Co, Zn complexes of the parent NSAID exhibited cytotoxicity with LC50 values 1.23 ± 0.91 μg/ml, 1.12 ± 0.12 μg/ml, 1.17 ± 0.56 μg/ml, 1.35 ± 0.24 μg/ml respectively, compared to the vincristine sulfate had LC50 value of 0.82 ± 0.09 μg/ml. Furthermore, 1,1-diphenyl-2-picrylhydrazyl assay revealed that in comparison with standard BHT had IC50 of 11.84 ± 0.65, Cu and Co complex of tolfenamic acid exhibited significant antioxidant or radical-scavenging properties with IC50 values 13.61 ± 0.58 μg/ml and 15.38 ± 0.09 μg/ml, respectively.
Conclusion: It can be postulated that metal complexes of tolfenamic acid have auspicious pharmacological effects: antimicrobial, cytotoxicity, and antioxidant potency. Hence, these complexes might have better therapeutic responses in future; notwithstanding, it needs further detailed analysis in other pharmacological perspectives.
