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(a) showing good growth of Ochrobactrum anthropi on routine media with colonies about 1mm in diameter, circular, low convex, smooth, shining, and entire; (b) showing O. anthropi growing readily on MacConkey agar with mucoid consistency.
Source publication
Introduction:Ochrobactrum anthropi is an opportunistic and rare human pathogen, which is seen widely in the environment. O. anthropi infections have been reported in both immunocompetent and immunocompromised individuals. There is no proper consensus on the diagnosis and management of O. anthropi related infections.
Case Report:We report a case of...
Contexts in source publication
Context 1
... peripheral enhancing collection involving all the rotator cuff muscles and marrow edema with a patchy enhancement of distal end of clavicle suggestive of osteomyelitis ( For O. anthropi, good growth is observed on routine media in 24 h. Colonies are about 1mm in diameter and appear circular, low convex, smooth, shining, and entire as shown in (Fig. 4) [22]. Isolates of O. anthropi have shown growth readily on MacConkey agar which appears mucoid consistency and are non-lactose fermenters as shown in (Fig. 4) [23]. Key tests useful in distinguishing O. anthropi from related organisms include their ability to hydrolyze urea, inability to hydrolyze esculin, and a negative ONPG test ...
Context 2
... ( For O. anthropi, good growth is observed on routine media in 24 h. Colonies are about 1mm in diameter and appear circular, low convex, smooth, shining, and entire as shown in (Fig. 4) [22]. Isolates of O. anthropi have shown growth readily on MacConkey agar which appears mucoid consistency and are non-lactose fermenters as shown in (Fig. 4) [23]. Key tests useful in distinguishing O. anthropi from related organisms include their ability to hydrolyze urea, inability to hydrolyze esculin, and a negative ONPG test [2]. There are no biochemical tests currently available that separate O. intrermedium from O. anthropi [24]; however, it has been suggested that colistin ...
Citations
... 5 O. anthropi was also implicated in severe osteomyelitis as an opportunistic infection in an immunocompromised patient. 6 Most reported cases are from developed countries. 7 We report a case of O. anthropi sepsis in a 15-month-old child at a rural hospital in Central River Region, the Gambia. ...
Key Clinical Message
Ochrobactrum anthropi (O. anthropi), a rare opportunistic pathogen, caused sepsis in a malnourished 15‐month‐old African child. Early detection and appropriate antibiotics led to full recovery, highlighting the importance of robust surveillance for emerging pathogens in vulnerable populations.
Abstract
While rarely causing infections, O. anthropi, a non‐fermenting, obligately aerobic, flagellated gram‐negative bacillus, demonstrates oxidase positivity and indole negativity. Traditionally, Ochrobactrum spp is considered a low threat due to its environmental abundance and mild virulence. It is, however, a multidrug‐resistant bacteria known for causing opportunistic infections in humans. O. anthropi is typically associated with catheter‐related bloodstream infections. The first documented case was in 1998; most cases have been reported in developed countries. We present a case of O. anthropi sepsis in a malnourished child in sub‐Saharan Africa. We report a case involving a 15‐month‐old African female who presented with symptoms and signs of protein‐energy malnutrition and sepsis. The blood culture revealed O.anthropi. We treated the child with the empirical first‐line antibiotics per the national guidelines, intravenous ampicillin and gentamicin for a week, and the child fully recovered. This report describes a rare case of O. anthropi sepsis with malnutrition in an African female child. O. anthropi is an emerging pathogen causing opportunistic infections in both immunocompetent and immunocompromised patients. We report that early bacterial detection, appropriate antibiotic susceptibility and antimicrobial management based on local antibiogram data may be essential for excellent patient outcomes. Additionally, we recommend more robust surveillance to detect such rare emerging pathogens.
Ochrobactrum anthropi, previously known as "Achromobacter group Vd", is a gram-negative, non-lactose-fermenting, obligate aerobic, indole-negative, oxidase-positive, urease-positive, motile bacillus. In recent years, it has emerged as a nosocomial infection agent especially in central venous catheters in both immunosuppressed and immunocompromised individuals. In this case report, a 56-year-old female patient who underwent dialysis for two days a week due to chronic kidney failure and had O. anthropi isolated in blood culture samples taken after fever increased is presented. In conclusion, it should be kept in mind that unusual microorganisms such as catheter-related O. anthropi may appear as causative agents in patients undergoing dialysis due to renal failure.
Introduction
Every year, millions of deaths are associated with the increased spread of antimicrobial resistance genes (ARGs) in bacteria. With the increasing urbanization of the global population, the spread of ARGs in urban bacteria has become a more severe threat to human health.
Methods
In this study, we used metagenome-assembled genomes (MAGs) recovered from 1,153 urban metagenomes in multiple urban locations to investigate the fate and occurrence of ARGs in urban bacteria. Additionally, we analyzed the occurrence of these ARGs on plasmids and estimated the virulence of the bacterial species.
Results
Our results showed that multidrug and glycopeptide ARGs are ubiquitous among urban bacteria. Additionally, we analyzed the deterministic effects of phylogeny on the spread of these ARGs and found ARG classes that have a non-random distribution within the phylogeny of our recovered MAGs. However, few ARGs were found on plasmids and most of the recovered MAGs contained few virulence factors.
Discussion
Our results suggest that the observed non-random spreads of ARGs are not due to the transfer of plasmids and that most of the bacteria observed in the study are unlikely to be virulent. Additional research is needed to evaluate whether the ubiquitous and widespread ARG classes will become entirely prevalent among urban bacteria and how they spread among phylogenetically distinct species.
