(a, b) Clinical images showing numerous keratotic papules and plaques distributed on the extremities. (c, d) Histopathology examination revealed multiple parakeratotic columns situated over epidermal invaginations with absence of granular layer, forming an array of cornoid lamellae (hematoxylin & eosin stain, c: 20Â, d: 100Â).

Contexts in source publication

Context 1

... topical calcipotriol 0.005% ointment and oral acitretin, but the clinical response was limited. One year later, liquid nitrogen cryotherapy was performed once per week for all skin lesions. Following cryotherapy, some annular papules and plaques regressed while others gradually increased in thickness and diameter, and became more hyperkeratotic ( Fig. 2a and b). Excisional biopsy of a hyperkeratotic plaque on the buttock was performed. Pathological examination showed epidermal verrucous hyperplasia with hyperkeratosis. Multiple parakeratotic columns situated over epidermal invaginations with absence of granular layer were also present, forming an array of cornoid lamellae ( Fig. 2c and d). No ...

Context 2

... ( Fig. 2a and b). Excisional biopsy of a hyperkeratotic plaque on the buttock was performed. Pathological examination showed epidermal verrucous hyperplasia with hyperkeratosis. Multiple parakeratotic columns situated over epidermal invaginations with absence of granular layer were also present, forming an array of cornoid lamellae ( Fig. 2c and d). No koilocytes were found in the epidermis. Therefore, a diagnosis of verrucous disseminated superficial porokeratosis was made. HIV screening and tumor survey including chest X-ray, abdominal ultrasound, and Gallium scan all showed normal results. The patient underwent excisional surgeries for some of the hyperkeratotic lesions for ...