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(a) X-ray diffraction patterns and (b) FTIR spectra of Fe3O4, Fe3O4@SiO2, Fe3O4@SiO2@Au, FSA-MIPs, and FSA-NIPs.
Source publication
In this study, a novel material of core–shell structured magnetic molecularly imprinted polymers (Fe 3 O 4 @SiO 2 @Au (FSA)-MIPs) was successfully prepared for the rapid and selective determination of 4-methylmethcathinone (mephedrone, 4-MMC). The adsorption capacity of FSA-MIPs is 34.7 mg·g ⁻¹ at 308 K, which is significantly higher than magnetic...
Citations
... Furthermore, the preparation process of MIPs is simple and exhibits high stability against harsh conditions. Due to the aforementioned advantages, MIPs show a great potential in chromatography, electrochemical sensors and biosensors, solid phase extraction, and also DDS (16)(17)(18)(19). ...
To address the undesirable reactions associated with matrine (MAT) injection in clinical settings, a high-loading drug delivery system (DDS) based on pH-sensitive molecularly imprinted polymer (MAT@MIPs) was prepared for the first time. The imprinted materials containing recognition sites for the matrine were formed by using carboxyl-functionalized multiwalled carbon nanotubes as a supportive matrix and dopamine as a cross-linker due to its exceptional biocompatibility. Subsequently, the optimal reaction conditions and adsorption performance of MAT@MIPs were systematically investigated. The obtained polymers were characterized and evaluated by Fourier transform infrared spectrometry, scanning electron microscopy, elemental analysis, and thermogravimetric analysis. Results indicated that the MIPs demonstrated a favorable imprinting factor (2.36) and a high binding capacity (21.48 mg·g⁻¹) for matrine. In vitro studies, we performed cell counting kit-8 assays in HepG2 cells, then the drug delivery capabilities of MAT-loaded MIPs were validated through light microscopy analyses, and the matrine content in culture medium was quantified using ultra high-performance liquid chromatography-mass spectrum synchronously. The facile fabrication of MAT@MIPs presents a viable solution for designing high-loading and pH-responsive DDS, which can offer a novel administration approach for drugs requiring injection in clinical applications.
... Molecular imprinting is a bionic molecular recognition technology based on the simulation of antigen-antibody, enzyme-substrate, and other biological molecular recognition specificities (11), The molecularly imprinted polymers (MIPs) obtained by this technique have the characteristics of structure predetermination and recognition specificity (12) and offer wide application possibilities as they can specifically adsorb and identify a variety of target compounds. Owing to these remarkable properties, MIPs have been widely used for chromatographic separation (13), solid-phase extraction (SPE) (14,15), chemical sensing (16), catalysis (14,17,18), drug delivery (19), and artificial enzymes (20). ...
Porous molecularly imprinted polymer (MIP) microspheres were synthesized via iniferter-suspension polymerization method, employing lenacil (LA) as the template molecule and methacrylic acid (MAA) as the functional monomer. The host–guest complexes formed using LA and MAA were characterized by hydrogen nuclear magnetic resonance and ultraviolet–visible absorption spectroscopy. The obtained results showed that the interaction between LA and MAA mainly relied on hydrogen bonding. The surface morphologies and chemical structures of the MIPs were characterized by scanning electron microscopy. MIPs were spherical in shape with a relatively regular sphericity, rough surface structure, and numerous small holes, which significantly reduced the mass transfer resistance of the template molecules and exhibited excellent recognition performance for template molecules. In addition, soil samples were pretreated with solid-phase extraction columns molecularly imprinted with LA, and analyzed by high-performance liquid chromatography. The recoveries of LA, bromacil, and terbacil were up to 89.65%, 53.17%, and 44.63%, respectively. The developed method showed a minimum detection limit of 10–50 µg·mL⁻¹. In view of the continuous increase of public requirements for pesticide residue detection, a versatile pretreatment method was developed that is green, rapid, simple, and can be miniaturized.
Ag/Fe3O4/SiO2@MWCNTs MNCs magnetic nanocomposites as an effective catalyst was employed for generating of imidazopyrimidine derivatives in high yields. The structure of synthesized nanoatalyst was confirmed by SEM, XRD, TEM, VSM, EDX and XPS analysis. These new compounds were synthesized by using multicomponent reaction of cyclic guanidine derivatives, electron deficient acetylenic compounds, tert‐butyl isocyanide, ethyl bromopyruvate and synthesized nanocatalyst in aqueous media at room temperature. It should be mentioned that the high performance of nanocatalyat was synthesized by using water extract of Petasits hybridus leaves, which was utilized in these reactions for many times to confirm the reusability of nanocatalyst. The antioxidant property of new synthesized imidazopyrimidine was evaluated by two procedures and compound 5 b have the high property relative to other compounds. Also, the antimicrobial activity of new generated imidazopyrimidine was evaluated by disk distribution process utilizing two kinds of Gram‐negative bacteria and Gram‐positive bacteria; proving bacterial growth was stopped by using of these compounds. Also, to better understanding reaction mechanism density functional theory (DFT) based quantum chemical methods have been applied. Applied to the preparation of imidazopyrimidine derivatives, this method has short reaction times, high product yields, and the ability to separate catalyst and product using simple procedures.
Magnetic molecularly imprinted polymers (MMIPs) are used as artificial antibody materials. MMIPs have attracted a great deal of interest because of their low cost, wide practicality, predetermination, stability and their ability to achieve rapid separation from complex sample environments by the action of external magnetic field. MMIPs can simulate the natural recognition of entities. They are widely used because of their great advantages in terms of high selectivity. In this review article, the preparation methods of Fe3O4 NPs and a detailed summary of the commonly used methods for amination modification of Fe3O4 NPs are introduced, preparation of Ag NPs of different sizes and Au NPs of various shapes and preparation methods of magnetic molecularly imprinted plasmonic SERS composite nanoparticles such as Fe3O4@Ag NPs, Fe3O4/Ag NPs, Fe3O4@Au NPs, Fe3O4/Au NPs, Fe3O4@Au/Ag NPs and Fe3O4@Ag@Au NPs are main summarized. In addition, preparation process and the current application of MMIPs prepared from magnetic molecularly imprinted plasmonic SERS composite nanoparticles incorporating different functional monomers in a nuclear-satellite structure are also presented. Finally, the existing challenges and future prospects of MMIPs in applications are discussed.
