Fig 4 - uploaded by Lucile Floeter Winter
Content may be subject to copyright.
1 ( a ) Urea cycle and arginine-citrulline-ornithine interconversion pathways. CPS1 carbamoyl phosphate synthetase, OCT ornithine carbamoyltransferase, ASS argininosuccinate synthetase, ASL argininosuccinate lyase, ARG arginase, CH citrulline hydrolase, AD arginine deiminase. Red boxes indicate enzymes of the urea cycle. Blue boxes indicate enzymes of arginine-citrullineornithine interconversion. ( b ) Enzymes of the ornithine-arginine metabolism in trypanosomatids (Modifi ed from Camargo et al. ( 1978 ), Batistoti et al. ( 2001 )). + and −, indicate detectable and undetectable activity of the indicated enzyme, respectively. nd not determined. The dashed circle highlights ARG activity. ( c ) Phylogenetic tree based on SSU rRNA data of trypanosomatids obtained by Fitch and Margoliash method. The bar represents 0.01 substitution/sequence position (Modifi ed from Briones et al. 1992 )
Similar publications
Arginase (ARG) is a metabolic enzyme present in two isoforms that hydrolyze l-arginine to urea and ornithine. In humans, ARG isoform 1 is also expressed in cells of the myeloid lineage. ARG activity
promotes tumour growth and inhibits T lymphocyte activation. However, the two ARG transgenic mouse lines produced so far failed
to show such effects. W...
L-Arginine metabolism plays a crucial role in determining the M1/M2 polarization of macrophages. The M1 macrophages express inducible nitric oxide synthase (iNOS), while the M2 macrophages express arginase 1 and metabolize arginine into nitric oxide and urea, respectively. The tumor microenvironment promotes M2 macrophage polarization and consequen...
Multiple myeloma (MM) remains an incurable malignancy of plasma cells despite constantly evolving therapeutic approaches including various types of immunotherapy. Increased arginase activity has been associated with potent suppression of T-cell immune responses in different types of cancer. Here, we investigated the role of arginase 1 (ARG1) in Vκ*...
Leishmaniasis is a disease which is caused by the protozoa Leishmania and is considered the second-highest cause of death worldwide by parasitic infection. Looking for the right chemotherapy against leishmaniases has been difficult because of the high toxicity of the most effective drugs. Computational Chemistry plays an important role in the resea...
Objective:
Milk holds an anti-inflammatory response that is particularly important to protecting infants against necrotizing enterocolitis. Milk might also exert anti-inflammatory effects in adulthood, including the oral cavity where macrophages of the oral mucosal control innate immunity defense. It remains unknown, however, whether milk can modu...
