a Evolution of paw thickness of mice infected with L. amazonensis and measured during 30 days of treatment; b Paw thickness of mice infected with L. amazonensis and at the thirtieth day of the treatment. CTRL—untreated group, GLU—group treated with Glucantime®, GLU + OZ OIL—group with Glucantime® plus ozonated sunflower oil; OZ OIL—group treated with ozonated sunflower oil; GLU + OZ OIL—group treated with Glucantime® plus non-ozonated sunflower oil. The values are the mean ± SEM of six experimental units. * Significantly different from GLU, GLU + OZ OIL, and OZ OIL (*P < 0.05). # Significantly different to Glu + oz. oil (#P < 0.05)

Contexts in source publication

Context 1

... to verify if non-ozonated oil was able to interfere with the parasites growing in other quantities, an experiment was conducted with promastigotes cultures in RPMI with non-ozonated oil containing amounts of oil equivalents to each treatment with ozonated oil. Supplementary Fig. 2 shows that only the highest quantity of non-ozonated oil interferes with parasite growth. ...

Context 2

... and OZ. OIL), and the group treated only with Glucantime® (GLU). However, no difference was demonstrated between CTRL and the group that received Glucantime® plus sunflower oil (GLU + CTRL OIL) groups; furthermore, this group showed a significant difference to GLU + OZ OIL, which had the best performance, reducing the size caused by leishmaniasis (Fig. 2). The CTRL increased by 48% in the paw thickness from the beginning of the treatment until the finish, while GLU + CTRL OIL increased by 33%. Likewise, when treated with only Glucantime® or only with ozonated oil, the animals increased paw thickness slightly, 10% and 7%, ...