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α-Cyperone inactivated the Akt/FOXO3a/NF-κB pathway in OGD-treated cardiomyocytes. Cardiomyocytes were treated with α-cyperone (60 μM) for 24 hours after OGD induction. (a) Expression of p-Akt, Akt, p-FOXOa3, FOXOa3, p-NF-κB, and NF-κB was monitored by WB. (b) Nuclear translocation of Akt, FOXOa3, and NF-κB was assayed by cellular immunofluorescence. All experiments were repeated three times, and the data were expressed as mean±SD. ∗P<0.01 (vs. CON). &P<0.05 (vs. OGD), &&P<0.01.
Source publication
Objective:
This study is aimed at investigating the mechanism of α-cyperone in oxygen and glucose deprivation- (OGD-) induced myocardial injury.
Methods:
Cardiomyocytes were exposed to OGD and then treated with α-cyperone. The cell counting kit-8 (CCK-8) assay and flow cytometry were performed to determine cell proliferation and apoptosis, respe...
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Citations
... Encouragingly, our study revealed that the administration of Jianqu significantly attenuated this inflammatory response ( Figure 5). Previous studies have shown that Polygoni Herba, Artemisiae Annuae Herba, Glycyrrhizae Radix et Rhizoma., and α-cyperone, exhibited anti-inflammatory activities through may pathway, like PI3K/Akt, NF-κB, and NLRP3 [42,[48][49][50][51][52]. These results indicated that Jianqu may also exert its anti-inflammatory effects through multiple pathways, but its specific mechanism needs to be further investigated. ...
