Figure 1 - available via license: Creative Commons Attribution 4.0 International
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a: Chemical structure of paritaprevir with the macrocyclic core highlighted in green. b: Representative crystal image of needle-like paritaprevir form α and MicroED pattern. c: Representative crystal image of rod-like paritaprevir form β and MicroED pattern. Scale bars corresponds to 2 µm.
Source publication
Paritaprevir is an orally bioavailable, macrocyclic drug used for treating chronic Hepatitis C virus infection. Its structures had been elusive to the public until recently when one of the crystal forms was solved by MicroED. In this work, we report the MicroED structures of two distinct polymorphic crystal forms of paritaprevir from the same exper...
Contexts in source publication
Context 1
... Paritaprevir (ABT-450, Figure 1) is one of the highest molecular weight drugs approved for oral administration. [11] It was developed by AbbVie and Enanta Pharmaceuticals as a potent inhibitor of hepatitis C virus (HCV) non-structural 3/4A protease which plays a vital role in viral replication and assembly. ...
Context 2
... c = 50.78 Å, and α = β = γ = 90˚) from a merged dataset with an overall completeness of 89%, and refined at 0.85 Å to an R1 value of 0.1472 (Table S1, Figure S1). The ab initio structure of form β was solved in the same orthorhombic space group P212121 but with significantly different unit cell size (a = 10.56 Å, b = 12.32 Å, c = 31.73 ...
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