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a A36 steel I-beam under a moment force in the cross-sectional area as described in a homework problem. b Simulation output where students can probe along the top edge of the cross-section and ascertain maximum stress to compare with analytical solutions. c The result derived by probing for stress values along the top edge of the I-beam cross-section where a moment is applied
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Background
Recent advancements in additive manufacturing have made 3D design a desirable skill in combating the historically slow development of biomedical products. Due to the broad applicability of additive manufacturing to biomedical engineering, 3D design and 3D printing are attractive educational tools for biomedical engineering students. Howe...
Citations
... [5][6][7] Compared with conventional manufacturing techniques in tissue engineering (e.g., compression molding, molten casting, and electrospinning), 3D bioprinting can rapidly and accurately transform computer-aided designs into complex 3D objects without the use of conventional manufacturing tools, such as molds and models. 8,9 Furthermore, 3D bioprinting can also facilitate the manufacture of ondemand medical products, highlighting its economic, efficiency, and precision advantages over conventional manufacturing technologies. 10,11 3D printing has been used to construct medical models since it was first reported by Hull et al., who described the first light-curing mold printing device in 1984. ...
Three-dimensional (3D) bioprinting is a promising additive manufacturing technology that uses imaging data and computer-assisted deposition of biological materials or cells to reconstruct complex 3D structures accurately. This technology has progressed rapidly, in part because of its integration across multiple disciplines and combination with other technologies for clinical applications. Advances in experimental research and clinical applications related to otorhinolaryngology have led to the development of diagnostic and treatment methods based on 3D bioprinting, including the development of tissue engineering scaffolds, biosensors, organ chips, and organoids, surgical planning, graft construction, and medical education. Additionally, otorhinolaryngologists will be better equipped to treat tissue function defects with personalized printed graft implants. It is also expected that 3D printing can be used to build ideal in vitro models in the future to help solve existing research challenges. This article briefly introduces the relevant 3D bioprinting technologies and bioinks that can be used by otorhinolaryngologists and discusses their potential applications in otorhinolaryngology.
... The creation of a novel artificial bone graft replacement material with strong mechanical properties as well as favourable bone healing capabilities may promote bone regeneration in clinical circumstances (Mandrycky et al., 2016;Deng et al., 2021). At present, the artificial hard tissue repair materials available in clinics and the medical materials market can be broadly divided into two categories (Jia et al., 2023). Calcium-based materials, like HA and β-tricalcium phosphate, are beneficial for their ability to provide strong bone guidance and degradation capabilities (Jia et al., 2021). ...
As a traditional bone implant material, titanium (Ti) and its alloys have the disadvantages of lack of biological activity and susceptibility to stress shielding effect. Adipose stem cells (ADSCs) and exosomes were combined with the scaffold material in the current work to effectively create a hydroxyapatite (HA) coated porous titanium alloy scaffold that can load ADSCs and release exosomes over time. The composite made up for the drawbacks of traditional titanium alloy materials with higher mechanical characteristics and a quicker rate of osseointegration. Exosomes (Exos) are capable of promoting the development of ADSCs in porous titanium alloy scaffolds with HA coating, based on experimental findings from in vitro and in vivo research. Additionally, compared to pure Ti implants, the HA scaffolds loaded with adipose stem cell exosomes demonstrated improved bone regeneration capability and bone integration ability. It offers a theoretical foundation for the combined use of stem cell treatment and bone tissue engineering, as well as a design concept for the creation and use of novel clinical bone defect repair materials.
Computer simulations play an important role in a range of biomedical engineering applications. Thus, it is important that biomedical engineering students engage with modeling in their undergraduate education and establish an understanding of its practice. In addition, computational tools enhance active learning and complement standard pedagogical approaches to promote student understanding of course content. Herein, we describe the development and implementation of learning modules for computational modeling and simulation (CM&S) within an undergraduate biomechanics course. We developed four CM&S learning modules that targeted predefined course goals and learning outcomes within the FEBio Studio software. For each module, students were guided through CM&S tutorials and tasked to construct and analyze more advanced models to assess learning and competency and evaluate module effectiveness. Results showed that students demonstrated an increased interest in CM&S through module progression and that modules promoted the understanding of course content. In addition, students exhibited increased understanding and competency in finite element model development and simulation software use. Lastly, it was evident that students recognized the importance of coupling theory, experiments, and modeling and understood the importance of CM&S in biomedical engineering and its broad application. Our findings suggest that integrating well-designed CM&S modules into undergraduate biomedical engineering education holds much promise in supporting student learning experiences and introducing students to modern engineering tools relevant to professional development.
