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Zika virus disease (Zika) is a disease caused by the Zika virus, which is spread to people primarily through the bite of an infected Aedes species mosquito. Zika virus is a flavivirus, in the family Flaviviridae, distributed throughout much of Africa and Asia. The most common symptoms of Zika are fever, rash, joint pain, and conjunctivitis (red eye...
Context in source publication
Context 1
... The Zik a virus genome encodes for a polyprotein with three structural proteins, capsid, premembrane/membrane, and envelope (including the envelope1 54 -glycosylation motif previously associated with virulence), and seven nonstructural proteins, NS1, NS2A, NS2B, NS3, NS4A, NS4B, and NS5 encod e s for (Fig.3). Virions located on the surface o f the cell membrane enter the host cells. ...
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We administered an anonymous survey to assess knowledge, attitudes, and prevention practices related to the Zika virus among pregnant women residing in Texas. Multivariate logistic regression models controlling for age, race/ethnicity, education, and number of years in the United States assessed differences between women born in outbreak areas (N =...
Purpose of review:
The purpose of this article is to review what is currently known about Zika virus (ZIKV) disease and associated neurologic complications.
Recent findings:
ZIKV is a mosquito-borne or sexually transmitted flavivirus rapidly spreading throughout the Americas. While ZIKV infection is usually asymptomatic, it may cause a non-speci...
Citations
Aim: This study aims to provide insight into the binding features of the ATPase and ssRNA sites of the NS3 helicase. Methods: Clinically approved Flavivirus inhibitors were docked to the corresponding active sites of the protein, and the three best compounds were validated with molecular dynamic simulations. Result: Binding of Ivermectin to ssRNA site and Lapachol and HMC-HO1α to the ATPase site allowed for conformational rigidity of the Zika NS3 helicase, thus stabilizing residue fluctuations and allowing for protein stability. Favorable free binding energies were also noted between compounds and the helicase, thus supporting the intermolecular forces at the helicase active site. Conclusion: The pharmacophoric characteristics found in Lapachol, HMC-HO1α and Ivermectin may be utilized in the design of a potent hybrid drug that is able to show efficient inhibition of a multitude of diseases including the detrimental co-infection of Zika virus, dengue and chikungunya.
