Figure 1 - available via license: Creative Commons Attribution 4.0 International
Content may be subject to copyright.
Download
View publication
XZ, YZ and XY slices through the centre of the tumour, showing how the volume is partitioned into planning target volume (PTV), proximal, distal boundary, distal and peripheral regions. The working volume is a 100 mm×100 mm×100 mm volume centred on the tumour, which in this specific example is 50 mm in diameter, offset to the side of a simplified spherical human head phantom (outer ⊘ = 200 mm, with 2 mm of skin and a 6 mm thick skull). An OAR with a diameter of 20 mm is located distal to the tumour and a 20 mm diameter hypoxic sub-volume is located on the inner edge of the tumour. The beam grid is 5 mm×5 mm, with beam entrance on the left. One beam (protons, 134.9 MeV) is shown at beam grid position (51, 51) mm, reaching the distal margin of the PTV.

XZ, YZ and XY slices through the centre of the tumour, showing how the volume is partitioned into planning target volume (PTV), proximal, distal boundary, distal and peripheral regions. The working volume is a 100 mm×100 mm×100 mm volume centred on the tumour, which in this specific example is 50 mm in diameter, offset to the side of a simplified spherical human head phantom (outer ⊘ = 200 mm, with 2 mm of skin and a 6 mm thick skull). An OAR with a diameter of 20 mm is located distal to the tumour and a 20 mm diameter hypoxic sub-volume is located on the inner edge of the tumour. The beam grid is 5 mm×5 mm, with beam entrance on the left. One beam (protons, 134.9 MeV) is shown at beam grid position (51, 51) mm, reaching the distal margin of the PTV.

Source publication
Figure 1. XZ, YZ and XY slices through the centre of the tumour,...
Figure 11. Labelled phantom sections and sections through the dose...
Simulation parameters used for the generation of the ion data library...
The percentage contribution of individual ions in each multi-ion...
+1 The percentage contribution of individual ions in each multi-ion...
A treatment planning system for manifold multi-ion particle therapy
Preprint
Full-text available
  • Dec 2022
This paper reports on the design of an open source treatment planning system for optimal multi-ion irradiation of a heterogeneous target with arbitrary spatial dose distributions. The developed TPS features controllable avoidance of dose in organs at risk and optional linear energy transfer enhancement in hypoxic target sub-volumes. The performance...
Cite
Download full-text

Contexts in source publication

Context 1
... distributions for each of the selected ion/energy combinations at this position are then calculated by scaling the homogeneous dose distributions along the z (depth) dimension using the previously-calculated PMMA-equivalent depth vector D ′ to give the spatial dose distributions expected in the heterogeneous 199 target (see Figure 1). These distributions are stored as part of the treatment plan data structure for later use 200 in the optimisation process together with a list of the actual energies used for this ion at this position. ...
Context 2
... results of the integrated simulation are shown in Figure 11. Visual examination of the slices through 382 the centre of the tumour illustrate the high degree of dose uniformity achieved in the tumour volume. ...
Context 3
... main difference between the planned and simulation dose which can be seen in Figure 11 is the 391 dose in air; this is neglected by the TPS since it has a negligible impact on the dose deposited in tissue (i.e. ...