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Background: Many studies have assessed the effects of either low intensity pulsed ultrasound (LIPUS) or demineralized bone matrix (DBM) on bone repair; however, an evaluation of the combination of these modalities (LIPUS + DBM) has not yet been considered.
Objectives: This study aimed to investigate combined effects of DBM and LIPUS on fracture hea...
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The present study evaluated the influence of Low-Intensity Pulsed Ultrasound (LIPUS) on the regeneration processes of non-critical-size bone defects in irradiated and non-irradiated rabbit tibias. Bone defects were surgically created on both tibiae of six rabbits. The control group had no additional treatment. In one intervention group, one tibia w...
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... Thus, LIPUS can directly stimulate the proliferation of osteoblasts mechanically, induce the ossification of cartilage, and increase bone mineralization. Other mechanisms of action of LIPUS include change in function of cell membrane and subsequently increased the level of cellular calcium, stimulation of fibroblast activity, increased protein synthesis, enhanced permeability of vessels and angiogenesis [19]. It seems that LIPUS increases the expression of genes involved in osteogenesis by osteoblasts such as Runt-related transcription factor-2, alkaline phosphatase, osteorix, and cyclin-D1, which explains the pro-osteogenesis effects of LIPUS [20]. ...
... Their results were different from ours, which may be due to the fact that they used a hand-made LIPUS device, so make their results incomparable to our findings. The clinical protocol for the application of LIPUS includes the application of 1 MHZ sine waves with 1 KHz frequency, a mean intensity of 30 mW/cm 2 and pulse width of 200 ms for 20 min a day [19]. However, no consensus has been reached regarding the frequency of LIPUS for therapeutic purposes. ...
Background and Objectives: Mechanical stimulation can improve the structural properties of the fracture site and induce the differentiation of different cell types for bone regeneration. This study aimed to compare the effect of low-intensity pulsed ultrasound stimulation (LIPUS) versus whole body vibration (WBV) on healing of mandibular bone defects. Materials and Methods: A mandibular defect was created in 66 rats. The rats were randomly divided into two groups of rats. Each group was subdivided randomly by three groups (n = 11) as follows: (I) control group, (II) treatment with LIPUS, and (III) treatment with WBV. The radiographic changes in bone density, the ratio of lamellar bone to the entire bone volume, the ratio of the newly formed bone to the connective tissue and inflammation grade were evaluated after 1 and 2 months. Results: LIPUS significantly increased the radiographic bone density change compared to the control group at the first and second month postoperatively (p < 0.01). WBV only significantly increased the bone density compared to the control group at the second month after the surgery (p < 0.01). Conclusions: Application of LIPUS and WBV may enhance the regeneration of mandibular bone defects in rats. Although LIPUS and WBV are effective in mandibular bone healing, the effects of LIPUS are faster and greater than WBV.
