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... However, in the presence of moderate to severe kyphoscoliosis, which is a common skeletal deformity in patients with Marfan syndrome, the US: LS ratio and armspan should not be tested. 2 Wrist sign is the overlapping of the thumb and fifth fingers when these encircle the opposite wrist ( Figure 1). Thumb sign (Steinberg sign) 2 is the extension of the thumb past the ulnar border of the hand, when apposed to the palm ( Figure 2). ...