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Workflow for the orthotopic and heterotopic tumor implantation. (a) 4T1 cells were inoculated at the breast. (b) Tumor tissues were extracted and cut into small pieces. (c-e) Tumor tissue fragments were drawn up into a 1-mL syringe with a 16G needle and were injected into the breast, skin, and liver in mice, separately.
Source publication
Background:
In experimental animal models, implantation location might influence the heterogeneity and overall development of the tumor, leading to an interpretation bias.
Purpose:
To investigate the effects of implantation location in experimental tumor model using magnetic resonance imaging (MRI) and pathological findings.
Study type:
Prospe...
Context in source publication
Context 1
... subcutaneous, and intrahepatic tumor models were successfully established in all the mice (Fig. 1). Figures 2 and 3 showed the images and quantitative parameters of tumors between three groups. Various degrees of hyperintensity were seen on DWI in the intrahepatic implanted tumor, brighter than those in the orthotopic and subcutaneous implanted tumors which were quantified by ADC values (hepatic vs. orthotopic vs. subcutaneous: ...
