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Waterfall plot with colors indicating the best response.

Waterfall plot with colors indicating the best response.

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Figure 1. Flowchart of patients submitted to the study team and reasons...
Figure 2. Waterfall plot with colors indicating the best response.
Figure 3. Progression-free survival and overall survival curves....
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Efficacy and Safety of Panitumumab in Patients With RAF / RAS -Wild-Type Glioblastoma: Results From the Drug Rediscovery Protocol
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  • Dec 2023
Background The prognosis of malignant primary high-grade brain tumors, predominantly glioblastomas, is poor despite intensive multimodality treatment options. In more than 50% of patients with glioblastomas, potentially targetable mutations are present, including rearrangements, altered splicing, and/or focal amplifications of epidermal growth fact...
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... patients achieved a PR and 3 patients had SD at 16 weeks. Figure 2 depicts the greatest changes in the sum of target lesions for each patient. The median PFS and OS were 1.7 months (95% CI 1.6-2.1 months) and 4.5 months (95% CI 2.9-8.6 months), respectively ( Fig. 3A and 3B). ...