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The metabolism of vitamin D (VD) is severely impaired in chronic kidney disease (CKD). Uremia is not only associated with the reduction of its active form 1,25-dihydroxyvitamin D but also in the reduction of all VD metabolites. CKD-associated abnormalities in VD are part of the CKD-related mineral-bone disease. However, VD has beneficial effect on...
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Context 1
... kidney plays a pivotal role in vitamin D (VD) metabolism. In the proximal tubules the enzyme 1α hydroxylase (CYP27B1) transforms 25-hydroxyvitamin D into the active metabolite 1,25-hydroxyvitamin D (Figure 1). 25-hydroxyvitamin D (25VD) is absorbed in the proximal tubule cells via megalin-dependent pathway. ...
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