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Vessel pathology of the left common carotid artery in an animal of the subacute experimental group. No inflammatory cell infiltration, thrombosis, tear, or dissection in the untreated segment (A) and distal (B), middle (C), and proximal (D) parts of the thrombectomy segments. Endothelial cells on the lumen surface were intact for all vessel segments.
Source publication
Background
and purpose: Stent retriever thrombectomy is the standard therapeutic approach for ischemic stroke with acute large-vessel occlusion. This study evaluated the safety and efficacy of a new thrombectomy device (Skyflow) in the treatment of acute ischemic stroke.
Methods
An arterial occlusion model was established, stent-retriever thrombec...
Context in source publication
Context 1
... on these vessel walls were relatively intact on histopathological examination. There was no inflammatory cell infiltration or thrombosis in the vessel lumen. No significant pathological differences were observed between the distal, middle, and proximal thrombectomy vessel segments and the distal vessel segment without simulated thrombectomy. Fig. 3 shows the histopathology of a blood vessel in group ...
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Background:
Filament perforation is a widely-used method to induce subarachnoid hemorrhage (SAH) in mice. Whereas the perforation site has been assumed to be in the branching of middle cerebral artery (MCA) and anterior cerebral artery (ACA), we recently observed more proximal perforations.
Methods:
Filament perforation was performed in CD1- (n...
Citations
... Intravenous thrombolysis was given to patients within 4.5 h of onset and without contraindications to intravenous thrombolysis (15). Patients undergoing EVT underwent a procedure that included a stent retriever device, aspiration, balloon dilatation, stenting, intra-arterial thrombolysis, or a combination of the above approaches (16,17). The modality of EVT was determined by an experienced surgeon. ...
Purpose
The relationship between sub-item scores on the National Institutes of Health Stroke Scale (NIHSS) scores and prognosis and intracranial hemorrhage in patients with acute ischemic stroke undergoing endovascular treatment (EVT) has been insufficiently studied. The aim of this study was to investigate the correlation between NIHSS sub-item scores, prognosis, and intracranial hemorrhage.
Methods
This study included patients with acute anterior circulation ischemic stroke undergoing EVT between February 2019 and April 2022. The outcomes included functional independence, defined as a modified Rankin Scale (mRS) score ≤ 2 at 3 months after EVT, intracranial hemorrhage within 24 h after EVT, and mortality within 3 months. A multivariate regression analysis was performed, including NIHSS sub-item scores and other adjusted variables.
Results
A total of 568 patients were enrolled. Of the 568 patients, 239 (45%) achieved functional independence at 3 months after EVT. The median age in this group was 63 years (IQR 52–69) and 176 (73.6%) were male patients. Intracranial hemorrhage within 24 h after EVT occurred in 170 (30%) patients. The median age in this group was 65 years (IQR 56–71) and 105 (61.8%) were male patients. In a multivariate analysis adjusted for age, gender, and factors with a value of p of <0.05, the NIHSS limb movement sub-item score was strongly associated with prognosis at 3 months (OR 0.833, 95% CI 0.758–0.915) and intracranial hemorrhage within 24 h after EVT (OR 1.161, 95% CI 1.037–1.300).
Conclusion
Higher limb movement sub-item scores on the NIHSS were independently associated with a poorer prognosis at 3 months and a higher rate of intracranial hemorrhage within 24 h after EVT among patients with acute anterior circulation ischemic stroke.
