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Verrucous epidermal nevus in the interscapular region, showing a darkened papule with pearly shine in its central portion.
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We report a case of basal cell carcinoma that appeared from an epidermal verrucous nevus in a 61-year-old patient. The onset of basal cell carcinoma in sebaceous nevi, basal cell nevi and dysplastic nevi is relatively common, but it is rarely associated with epidermal verrucous nevi. There is no consensus on whether the two lesions have a common ce...
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We describe an extraordinary case of a nevus of Ota with intraoral mucosal involvement. We performed a selective review of the English literature and discuss the potential malignant behavior when the oral mucosa is involved.
Citations
... Studies have reported malignant transformation of epidermal nevi associated with squamous cell carcinoma, Bowen's disease, and keratoacanthoma 2) . Nevertheless, very few reports have reported the emergence of basal cell carcinoma in epidermal nevi ( Table 1) [3][4][5][6][7][8] . Published case reports of basal cell carcinomas developing from epidermal nevi generally mention a recent phenotypic change in the lesion (e.g., tumor enlargement, pain, bleeding, exudates, nodules, and crusting). ...
An epidermal nevus is known to appear at birth or in early childhood. Generally, it does not undergo major changes throughout life and can be left untreated. We report a case of basal cell carcinoma arising from an epidermal nevus in a 79-year-old man with congenital linear brown epidermodysplasia and nodular lesions on the right posterior neck. He had no other symptoms that could be attributed to epidermal nevus syndrome. He reported leakage of exudate from the nodule in recent years. Upon resection, the histopathological examination revealed an eccrine sweat gland tumor and basal cell carcinoma in a portion of the epidermal nevus. Cases of malignant tumors (e.g., squamous cell carcinoma and basal cell carcinoma) arising from an epidermal nevus have been reported previously. Nevertheless, preventive resection is not recommended in all cases. Epidermal nevi, even those left untreated or with changed properties, are rarely malignant.
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... [2] In our case, it was associated with lobster claw hand which is quite unusual. Other rare associations of inflammatory verrucous epidermal nevus include arthritis, basal cell carcinoma, [3] porokeratotic eccrine ostial and dermal duct nevus, [4] neurofibromatosis, [5] lichen amyloidosis, [6] and wooly hair nevus. Lobster claw hand, a rare congenital anomaly, also known as ectrodactyly or split hand foot malformation refers to central deficiencies of the hand, developing as a result of the longitudinal failure of the formation of 2 nd , 3 rd , or 4 th ray. ...
... It is uncommon for multiple tumor types to develop within a single NS, although multiple types of tumors can occur within NS lesions. BCC alone within NS has been noted in some cases predominantly affecting the trunk and scalp [4,5]. BCC and sebaceoma have rarely been documented to occur concurrently within an NS. ...
This case describes the occurrence of basal cell carcinoma (BCC) and sebaceoma within a nevus sebaceous (NV), which has not yet been previously reported. This is significant to dermatologists as it emphasizes the importance of close monitoring of benign sebaceous nevi in the event that malignant transformation occurs, although such occurrences are rare. Prompt consideration for prophylactic excision of NS is warranted prior to malignant transformation.
... However, the diagnostic accuracy is dependent on the dermatologist's experience so that 21.7% SK have been misdiagnosed as BCC, 2 31.8% BCC have been misdiagnosed as SK, 2 and up to 28% melanocytic nevus have been misdiagnosed as SK. 3 To make things more complicated, BCC may arise within SK and nevus, 4,5 and BCC is the most common malignant neoplasm occurring within SK. 5,6 The consequence is unnecessary tumor removal and treatment costs incurred due to the false-positive clinical diagnosis. To date, the gold standard of skin diagnosis is still the excisional biopsy followed by histological analysis. ...
Background:
Basal cell carcinoma, seborrheic keratosis, and nevus are common skin conditions. Though most of the skin diseases can be distinguished from each other by physician's naked eyes, the diagnostic accuracy is not 100%. The accurate diagnosis and assessment of three diseases make a big difference on the clinical management. Nowadays, biopsy is still the gold standard for diagnosis even it is invasive, time-consuming, and painful. Ultrahigh-resolution optical coherence tomography is an emerging technology that can produce in situ, cellular-resolution, real-time, continuous, 3D images in a noninvasive way.
Materials and methods:
In our study, four basal cell carcinoma patients, five seborrheic keratosis patients, and 10 nevus patients who were diagnosed by histology were studied by ultrahigh-resolution optical coherence tomography after visual examination by experienced dermatologists. Cellular contrast was utilized to clearly identify the features of the three skin diseases.
Results:
The features including such as hyperkeratosis (horn pseudocysts), papillomatosis, intraepidermal nests, elongated, and expanded rete ridge can be visualized in seborrheic keratosis. Tumor nodular, mucin surrounding with tumor (retraction space in histopathology), tumor subtype, and necrosis were featured in basal cell carcinoma. Pigment was characterized in epidermis and dermis. The comparison of ultrahigh-resolution optical coherence tomography images reveals a strong correlation with histological images.
Conclusion:
Ultrahigh-resolution optical coherence tomography can complement existing diagnostic techniques for investigating seborrheic keratosis, basal cell carcinoma and nevus, and show enormous potential in vivo applications for the three skin diseases in the future.
... Rarely, neoplastic transformation into squamous cell carcinoma, basal cell carcinoma have been reported in few cases. 17,18,19 Inflammatory linear verrucous epidermal nevus (ILVEN) also known as eczematous epidermal nevus, is a variant of VEN. It is clinically inflammatory in nature with psoriasiform histopathology. ...
... Within the past few months the papular lesions were pruritic with contact bleeding and became ulcerated with crust formation ( Figure 1). Based on the history and as a pearly shiny papule within the epidermal naevus ( Viana et al. 2015). Ulceration and shiny papule with rolled edges are classical presentations of basal cell carcinoma. ...
ABSTRAK Epidermal naevus adalah hamartoma kulit kongenital yang benigna. Kami mengetengahkan kes yang jarang ditemui iaitu epidermis naevus dengan transformasi malignan untuk karsinoma sel basal. Seorang lelaki berusia 79 tahun telah dibiopsi untuk nodul kulit berukuran 2 x 4 cm yang timbul di dalam lesi papular linear berukuran 2 x 4 cm di sebelah kiri lehernya. Nodul itu kemudiannya disahkan sebagai karsinoma sel basal yang timbul daripada epidermal naevus. Mutasi gen PIK3CA mutasi dikaitkan dengan karsinoma sel basal, yang menunjukkan komponen sel karsinoma basal adalah bebas daripada komponen epidermis naevus. Doktor klinikal dan pakar patologi perlu sedar kemungkinan perubahan malignan yang mungkin timbul dalam epidermal naevus. Kata kunci: karsinoma sel basal, BCC, epidermal naevus ABSTRACT Epidermal naevus is a congenital cutaneous hamartoma with a benign course. We highlight a rare case of epidermal naevus with concurrent basal cell carcinoma. A 79-year-old male had a skin biopsy at our centre for an enlarging skin nodule within a linear papular lesion measuring 2 x 4 cm at the left side of his neck, which was later diagnosed as basal cell carcinoma arising from an epidermal naevus. PIK3CA mutation is attributed to basal cell carcinoma which suggests the basal cell carcinoma component is independent of the epidermal naevus component. Clinicians and pathologists must be aware of possible malignant changes that might arise in an epidermal naevus.
Congenital melanocytic naevi (CMN) are common skin lesions. They harbour a risk of malignant transformation, and various lesions have been described as developing within them. A basal cell cancer occurring within a CMN has never previously been described. A case is described of a woman aged 52 years presenting with a slow-growing, symptomatic 3 cm lesion in the centre of a 10×5 cm CMN on her right upper back. Diagnostic core biopsy revealed an ulcerated, infiltrative basal cell carcinoma which was then further excised. The scar has healed with no evidence of local recurrence at 1-year follow-up.
