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To report our experience of the clinicopathological patterns of diffuse parenchymal lung disease (DPLD).
Over a 4-year period, 75 patients (41 males, 34 females), aged 13-76 years, who were referred to Mubarak Al-Kabeer and the Chest Diseases Hospitals, Kuwait with a diagnosis of diffuse lung disease, were included in the study. After a comprehensi...
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Context 1
... the 75 patients, 34 (45%) had symptoms of less than 6 months in duration, while 28 (16%) had symptoms for over a year before presentation; 34% were cigarette smokers. IPF was the most common DLPD, occurring in 69% of the cases, followed by sar- coidosis, collagen vascular disease, BOOP and extrinsic allergic alveolitis (table 2). ...
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Background and objective:
The COPD Assessment Test (CAT) has been reported to have potential utility for measuring health status of idiopathic pulmonary fibrosis (IPF). Although the CAT has been developed for the assessment of COPD patients, it has not been fully evaluated exclusively in IPF. This study was designed to evaluate the validity of the...
Citations
... 9 Abul et al. , reported that crackles were presents in 93% patients and clubbinging in 75% patients of DPLD . These reports comparable with the present study 25 . ...
... . In the study done by Maheswari et al., 20% cases were smokers and study by Abul et al., 34% cases were smokers9,25 .Out of 45 cases of DPLD the most common disease was collagen vascular disease (31%), followed byFig 1). Progressive systemic sclerosis and rheumatoid arthritis are the most frequent encountered collagen vascula r disease in our study (Table 7). ...
This prospective study was carried out on clinical, serological and radiological findings at Chest Clinic of J. L. N. Hosp Chhattisgarh India. Patient's samples were obtained from 45 DPLD patients characteristics, including age, sex and detailed history was recorded. P patients at the time of initial presentation patients. DPLD group had statistically to control (3.27±0.70). In conclusion, chronic DPLD patient and its effect on P have diagnostic potential in evaluation
... It has been difficult to define the epidemiology of ILD in SSc with any degree of accuracy, this reflect the fact that SSc is rare disease (estimated prevalence 30-500/million) (14). Previous studies of ILD suggest that therapeutic and prognosis responses are influenced by the presence of underlying connective tissue disorders (8). ...
OBJECTIVE: To report the prevalence of interstitial lung disease in Systemic Sclerosis patients at the Royal Hospital and compare our data with the literature. METHODS: All adult Omani patients with Systemic Sclerosis (SSc) who are under regular follow-up at the Royal Hospital were retrospectively enrolled from January 2006 to January 2014. RESULTS: A total of 49 cases of Systemic Sclerosis (SSc) patients were included. The mean age was 44.06 ± 11.9 years. There was a predominance of females (48 cases; 98%). Interstitial lung disease present in 30 cases (61%). The most frequent symptoms were dyspnea 47%, cough 33%, and others (e.g. atypical chest pain) 20%. There was no association with smoking, non-smoker (47 cases, 95.5%) versus ex. smoker (2 cases, 4%). The most high resolution computed tomography (HRCT) finding was traction bronchiectasis (21 cases, 42.9%) followed by honey comb appearance (19 cases, 38.8%). Pulmonary Function Test (PFT) was done in 33 cases. The mean total lung capacity (TLC) was 81. 06 ± 26.2. The mean diffusion lung capacity (DLCO) was 61.8± 28.3. Pulmonary hypertension was found in 10 cases only (20.4%) based on echocardiography. CONCLUSIONS: ILD was present in 30 cases out of 49 cases of SSc (61.2%) with female predominance. The most frequently observed HRCT change was traction bronchiectasis. Similarities and differences were found with respect to the previous reports from other countries.
... In asymptomatic patients, enlargement of the salivary glands is the first identifiable sign of the disease [8]. Involvement of salivary glands has been reported in the maxillofacial region that xerostomia or bilateral parotid swelling is the result of this involvement [26,27]. Inflammation of salivary glands differentiates OFG from other granulomatous diseases such as cheilitis glandularis, Wegener's granulomatosis, sarcoidosis, and deep fungal infections [28]. ...
... Cigarette smoking was found to be the main cause for oral cancer and lung diseases than other causative factors (Hijazi et al. 2002;Abul et al. 2004;Al-Shammari et al. 2006). Satarug (2012) and Kweon et al. (2012) observed a definite link between ETS exposures and lung and heart diseases. ...
Environmental tobacco smoke is an important factor in indoor air quality and public health. In this study, the impacts of cigarette smoking on the characteristics of PM10, PM2.5, and PM1 and their corresponding toxic metals in 50 indoor environments before and after smoking from 10 popular cigarette brands sold in Kuwait were investigated. Misleading advertisement branded ‘medium strong’ with less nicotine volume instigates the smokers use more cigarettes that may cause human health effects. Results showed high PM10 level (range 150–1100 µg m⁻³) followed by PM2.5 (range 100–880 µg m⁻³) and PM1 (range 52–530 µg m⁻³) after smoking. Establishment-wise, highest levels of particulate regardless the sizes were found in storehouse and lowest were observed in offices. The mean PM2.5/PM10 and PM1/PM2.5 ratios were in the range of 0.73–0.86 and 0.66–0.80, respectively, after smoking demonstrating that indoor PM10 was mostly composed of fine particles, which confirms that cigarette smoke had a dominate impact on the presence of smaller particles. Toxic metals level exhibited similar patterns as those observed in particulate in the sequence of Pb > Cd > Sb > Ba > Hg. This study recommends the preventive measures and suggests policy makers to take stringent measures against cigarette smoking in Kuwait to protect public health.
... 80 patients of ILD were included in the study and in this study there were 64 (80%) patients >40 years of age, which is comparable to a study done in Kuwait. 3 A study from India found that peak incidence was between 40-49 years' age group and then 30-39 years' age group. 4 Jindal et al showed that peak incidence was between 30 to 59 years. ...
... Sarcoidosis (20%), and Hypersensitivity Pneumonitis (6.3%). 3 In our study, IPF was more common in males (71%) than females (29%). Similar observations were made in the study conducted by Turner et al, where out of 220 IPF cases 66.8% were males and 32.2% were females. ...
OBJECTIVE
To know the clinical and radiological profile of patients of Interstitial Lung Diseases attending the Chest Hospital of Medical
College from North India from February 2014 to December 2015.
MATERIAL AND METHODS
The study was conducted in Department of Tuberculosis and Respiratory Diseases, G.S.V.M. Medical College, Kanpur (India). The
patients were subjected to complete clinical history (Including work environment and occupational history), physical examination,
various haematological investigations, spirometry and high resolution computerized tomography thorax.
RESULTS
In present study a total of 80 patients with interstitial lung disease were analysed. There were 36 males and 44 females (mean
age was 54.4±1.8 years). Of 80 patients of interstitial lung diseases examined, Idiopathic Pulmonary Fibrosis (IPF) pattern was
present in maximum number (38.8%) followed by sarcoidosis (17.5%), Hypersensitivity pneumonitis (15%) Non-specific interstitial
pneumonias (10%), Connective Tissue Disorder (C.T.D.) associated ILD (7.5%) and Cryptogenic Organizing Pneumonias (C.O.P.) in
5% of cases.
CONCLUSION
IPF was the most common subgroup among ILDs.
... Some studies confirm a genetic predisposition to sarcoidosis and present evidence for the allelic variation at the HLA-DRB1 locus as a major cause [22] . In the maxillofacial region, the salivary glands are often involved, and this may cause xerostomia or bilateral parotid swelling [23][24][25] . The involvement of the oral cavity seems to be rare with an unknown prevalence. ...
Orofacial granulomatosis (OFG) is an uncommon disease characterized by persistent or recurrent soft tissue enlargement, oral ulceration and a variety of other orofacial features. It could be an oral manifestation of a systemic disease. For a correct differential diagnosis, local and systemic conditions characterized by granulomatous inflammation should be excluded using appropriate clinical and laboratory investigations. In fact, the diagnosis of OFG may be confirmed only by histopathological identification of noncaseating granulomas. The literature from 1943 to 2014 was reviewed with emphasis on the etiology of OFG and on clinical manifestations of systemic pathologies associated with OFG. The precise cause of OFG is still unknown, although several theories have been suggested, such as infection, hereditary factors and allergy. OFG is a disease that has a wide spectrum of presentation, which may include the oral manifestation of a systemic condition such as Crohn's disease, sarcoidosis, granulomatosis with polyangiitis and Melkersson-Rosenthal syndrome. © 2015 S. Karger AG, Basel.
... Interstitial lung diseases (ILD) consist of a group of complex diseases, including more than 200 diseases (1), the commonest being idiopathic pulmonary fibrosis (IPF) (2,3). ...
... In most reported articles up to 75% of IPF patients were smokers (18,19). However, this rate in our study was about 18%, a rate which was lower than other statistics (2,5,16). ...
Background: IPF is the most common form of interstitial lung disease. IPF is a clinico-pathological syndrome characterized by cough, exertional dyspnea, basilar crackles, a restrictive pattern on pulmonary function test (PFT) and honey comb pattern on HRCT. Since there are no exact data on IPF in Iranian patients and also the controversy that exist in this regard we decided to study the IPF cases in regard to epidemiologic, clinical features, radiologic manifestations and diagnosis in Masih Daneshvari Hospital during 1998-2001. Materials and Methods: This study was a descriptive retrospective study on files of IPF patients in Masih Daneshvari Hospital during 1998-2001. Although the total number of patients was 98, only 50 cases that had clinical and pathological findings compatible with IPF were included in the study. Results: Twenty-seven (54%) were males and 23 (46%) were females. Mean age was 56.25 ±15.86 yrs. The most common clinical signs and symptoms were dyspnea (100%), cough (90%) and crackle (90%). HRCT findings were abnormal in all patients. Eighteen percent were smokers and the most common occupational exposure was through agriculture. 82.2% of patients had restrictive pattern on PFT. Seventy percent of patients had transbronchial lung biopsy (TBLB), 26% had open lung biopsy (OLB) and 4% had video-assisted thoracoscopy (VATS). Conclusion : Age of patients with IPF in our study is one decade lower than in Western countries. HRCT and TBLB assist significantly in the diagnosis of IPF and limiting the surgical procedures to only a limited number of cases. (Tanaffos 2006; 5(2): 27-32)
Objective: To determine the accuracy of High Resolution Computed Tomography in the evaluation of Diffuse interstitial lung disease. Study Design: Descriptive study. Place and Duration of Study: This study was conducted in the Department of Diagnostic Radiology, Pakistan Institute of Medical Sciences, Islamabad during the year June 2008 to December 2008. Materials and Methods: 30 patients were selected from OPD and Emergency department with history, clinical signs and plain chest radiograph suggestive of diffuse lung disease. Multi-slice high resolution spiral CT scanner "Asteion VR" (Toshiba) was used to conduct the study with High Resolution Computed Tomography (HRCT) protocol used in the evaluation of diffuse lung disease. Results: The 30 patients included in this study comprised of 15 male and 15 females with a male to female ratio of 1:1. The mean age of patients was 50.33 years. Cough was present in 100% of patients, dyspnea (83%), hemoptysis (17%), body aches (43%), joint pains (13%), and occupational exposure (23%). Different clinical signs were wheezing (70%), coarse crepitation's (47%) and clubbing (7%). In this study of all 30 patients (n=30) sarcoidiosis was (23%), pneumoconiosis (27%), idiopatfiic pulmonary fibrosis (20%), extrinsic allergic alveolitis (7%), lymphangitic carcinomatosa (10%) and systemic sclerosis (3%). Normal or non-diagnostic chest X-rays were seen in 20% patients which were then diagnosed by HRCT. The inter observer agreement on chest X-rays was found to be around 27% and that of HRCT is 52%. Conclusion: HRCT is the diagnostic tool of choice in the diagnosis of diffuse interstitial lung disease.
Bacterial urinary tract infections (UTIs) frequently occur in the outpatient as well as in the nosocomial setting. The stratification into uncomplicated and complicated UTIs has proven to be clinically useful. Bacterial virulence factors on the one hand, and the integrity of the host defense mechanisms on the other, determine the course of the infection. Late complications or sequelae might ensue if the defense mechanisms are disturbed, either by a genetic or an acquired cause. Escherichia coli is the most prevalent organism in uncomplicated UTIs, whereas the bacterial spectrum is much broader in complicated UTIs, including Gram-negative and -positive, and often multiresistant organisms. Therapy for uncomplicated UTIs is almost exclusively antibacterial, whereas in complicated UTIs the complicating factors need to be treated as well. The success of antibiotic therapy of UTIs in a population can be estimated by four parameters: the minimal inhibitory concentrations of the clinical isolates, the pharmacokinetic and pharmacodynamic profiles, and the protein binding of the treatment drug. In uncomplicated UTIs, antimicrobial therapy is usually empiric, whereas in complicated UTIs antibiotic therapy should be more individualized; tailored to the individual patient.
Bacterial urinary tract infections (UTIs) are frequent infections in the outpatient as well as in the nosocomial setting. The stratification into uncomplicated and complicated UTIs has proven to be clinically useful. Bacterial virulence factors on the one side and the integrity of the host defence mechanisms on the other side determine the course of the infection. In uncomplicated UTIs, Escherichia coli is the leading organism, whereas in complicated UTIs, the bacterial spectrum is much broader, including Gram-negative, Gram-positive and often multiresistant organisms. The therapy of uncomplicated UTIs is almost exclusively antibacterial, whereas in complicated UTIs the complicating factors also have to be treated. There are two predominant aims in the antimicrobial treatment of both uncomplicated and complicated UTIs: i) rapid and effective response to therapy and prevention of recurrence of the individual patient treated; and ii) prevention of emergence of resistance to chemotherapy in the microbial environment. The aim of this review is to highlight the existing, and to describe emerging, treatment options for UTIs.
