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Urine Composition and Abnormalities of Study Population* 

Urine Composition and Abnormalities of Study Population* 

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INTRODUCTION: This study was aimed to evaluate the correlation of body mass index (BMI), waist circumference (WC), and waist-stature ratio (WSR) with urinary composition in urolithiasis patients. MATERIALS AND METHODS: Medical reports of 1410 urolithiasis patients referred to a tertiary in Tehran, from 2010 to 2015, were reviewed. Collected data i...

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... composition and abnormalities are depicted in Table 2. The men had significantly higher creatinine, calcium, sodium, magnesium, oxalate, phosphorus, COSS, and UASS levels, while they had significantly lower citrate values, compared to the women. ...
Context 2
... men had significantly higher creatinine, calcium, sodium, magnesium, oxalate, phosphorus, COSS, and UASS levels, while they had significantly lower citrate values, compared to the women. In addition, the men had significantly higher abnormal values of calcium, sodium, citrate, oxalate, and UASS, whereas they showed lower rate of low magnesium compared to the women (Table 2). The linear association between obesity indexes and urine composition are shown in Tables 3 and 4. ...

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Objectives To investigate potential oxalate‐degrading bacteria, including Oxalobacter formigenes, Lactobacillus (Lac) and Bifidobacterium (Bif) genera, and Oxalyl‐CoA decarboxylase (oxc) encoding Lac (LX) and Bif (BX) species in participants with recurrent calcium kidney stones, and their correlation with 24‐h urine oxalate. Participants and Methods Stool and 24‐h urine samples were collected from 58 patients with urolithiasis (29 cases with and 29 without hyperoxaluria) and 29 healthy controls. Absolute quantitation and relative abundance of the bacteria were measured by real‐time PCR. The relationship between the investigated bacteria and 24‐h urine oxalate were assessed statistically. Results The count per gram of stool and relative abundance of O. formigenes, Lac, Bif, LX and BX and the number of participants carrying O. formigenes, LX and BX bacteria were not significantly different between the groups; however, the relative abundance of O. formigenes in the kidney stone group was lower than in healthy controls (P = 0.035). More healthy controls were O. formigenes‐positive compared with participants in the kidney stone group (P = 0.052). The results of the linear regression model, including all study participants, showed that the presence of O. formigenes could decrease 24‐h urine oxalate (β = −8.4, P = 0.047). Neither Lac and Bif genera nor LX and BX species were correlated with calcium stones or urine oxalate. Conclusion These results emphasize the role of O. formigenes in kidney stone formation and its role in hyperoxaluria, which may be independent of kidney stone disease. Moreover, our results suggest that, although some Lac and Bif strains have oxalate‐degrading potential, they may not be among the major oxalate‐degrading bacteria of the gut microbiome.