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Source publication
Aims
To analyze the clinical characteristics and prognostic factors of Chinese patients with colon cancer.
Methods
A retrospective analysis of the records of patients with colon cancer underwent surgery between 2014 and 2017 was performed. Univariate analysis in combination with Cox proportional hazard regression model was used to analyze the surv...
Context in source publication
Context 1
... 3-year survival rate of stage I, II, III and IV patients were 76.9%,97.3%,83.3% and 45.7%, respectively, and the 5-year survival rate of stage I, II, III and IV patients were 76.9%, 91.0%, 64.9% and 34.6%, respectively, with statistically significant difference (P < 0.01) ( Table 3) ( Figure 6). CEA, CA 19-9, CA125 and CA72-4 are common gastrointestinal tumor markers. ...Citations
... However, the participation rate of colonoscopy screening remains low in China [4]. A study showed that CRC cases with distant metastasis account for 25% [5]. Great progress has been made in surgical technique and adjuvant therapy, however, the five-year survival rate is not satisfactory in CRC patients with distant metastasis [6][7][8]. ...
Background
Replication factor C subunit 2 (RFC2) participates in the growth and metastasis of various malignancies. Our study investigated the roles of RFC2 in colorectal cancer (CRC).
Results
RFC2 expression was upregulated in CRC tissues and cells. High RFC2 expression was associated with poor prognosis. Knockdown RFC2 inhibited proliferation, induced apoptosis, and suppressed migration and invasion of CRC cells. CREB5 was a transcription factor of RFC2, and CREB5 knockdown suppressed RFC2 expression. Furthermore, RFC2 promoted aerobic glycolysis and MET/PI3K/AKT/mTOR pathway.
Conclusion
RFC2 promoted the progression of CRC cells via activating aerobic glycolysis and the MET/PI3K/AKT/mTOR pathway.
