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Ultrasound Image of Non-Effusive Knee with and without Pneumatic Compression (medial knee). The figure on the left is the flexed non-effusive knee, where the needle (Needle) cannot access the synovial fluid because the fat pad (Fat Pad) forces fluid from the surface of cartilage to the superior knee (Cartilage). The figure on the right is non-effusive knee with the pneumatic compression that compresses the suprapatellar bursa and inducing collapse driving the occult synovial fluid (Occult Extractable Fluid) inferiorly where the fluid collects over the cartilage surfaces (Cartilage) of the medial femoral condyle (Medial Femoral Condyle) displacing the fat pad (Fat Pad). The synovial fluid (Occult Extractable Fluid) can then be accessed by the needle (Needle).

Ultrasound Image of Non-Effusive Knee with and without Pneumatic Compression (medial knee). The figure on the left is the flexed non-effusive knee, where the needle (Needle) cannot access the synovial fluid because the fat pad (Fat Pad) forces fluid from the surface of cartilage to the superior knee (Cartilage). The figure on the right is non-effusive knee with the pneumatic compression that compresses the suprapatellar bursa and inducing collapse driving the occult synovial fluid (Occult Extractable Fluid) inferiorly where the fluid collects over the cartilage surfaces (Cartilage) of the medial femoral condyle (Medial Femoral Condyle) displacing the fat pad (Fat Pad). The synovial fluid (Occult Extractable Fluid) can then be accessed by the needle (Needle).

Source publication
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Full-text available
Objectives – Aspiration of synovial fluid from non-effusive joints is undertaken for the diagnosis of crystal-associated arthritis, biomarker analysis, and to confirm intraarticular positioning. We hypothesized that pneumatic compression of the non-effusive knee would mobilize occult synovial fluid and improve arthrocentesis success. Methods – The...

Contexts in source publication

Context 1
... this way, without the use of human hands susceptible to needle stick, the thigh cuff applies constant compression to the suprapatellar bursa, the synovial compartments of the superior medial and lateral knee, and patellofemoral joint, thus, collapsing these synovial compartments and forcing fluid inferiorly to the synovial reflections of the femoral condyles and cruciate ligaments where the fluid could be accessed ( Figures 2 and 3). After the pneumatic cuff was inflated to 100 mm Hg on the superior knee, 1-3 minutes were permitted to allow occult fluid to move from the superior knee to the inferior knee where it could be accessed ( Figure 3). Arthrocentesis success, and fluid yield again were recorded. ...
Context 2
... inability to fully extract synovial fluid from the non-effusive knee is due to minimal resident synovial fluid, the thin synovial fluid layer over the cartilage surfaces, mistargeting by the needle, and the complex foldings of the villi and discrete intraarticular synovial compartments that retain viscous occult synovial fluid [9,10,[21][22][23][24][25][26][27][28][29]36,37]. The present study demonstrates that external pneumatic compression of the noneffusive knee (Figure 1) mobilizes occult synovial fluid, dilates the joint space target with displaced occult fluid ( Figure 2) and permits fluid flow to the femoral condyles where the synovial fluid can be accessed using the anterolateral portal (Figure 3) [19,[37][38][39][40][41][42]. ...
Context 3
... despite pneumatic compression forcing synovial fluid from the suprapatellar bursa and superior knee to the femoral condyles where the fluid could be accessed, the fluid over the femoral condyle was layered quite thin dimensionally due to the restricted compressibility of adjacent fat pad (Figures 2 and 3). Thus, the needle often had to be rotated in the long axis so that the needle bevel was properly positioned in the fluid layer ( Figure 3). ...
Context 4
... this way, without the use of human hands susceptible to needle stick, the thigh cuff applies constant compression to the suprapatellar bursa, the synovial compartments of the superior medial and lateral knee, and patellofemoral joint, thus, collapsing these synovial compartments and forcing fluid inferiorly to the synovial reflections of the femoral condyles and cruciate ligaments where the fluid could be accessed ( Figures 2 and 3). After the pneumatic cuff was inflated to 100 mm Hg on the superior knee, 1-3 minutes were permitted to allow occult fluid to move from the superior knee to the inferior knee where it could be accessed ( Figure 3). Arthrocentesis success, and fluid yield again were recorded. ...
Context 5
... inability to fully extract synovial fluid from the non-effusive knee is due to minimal resident synovial fluid, the thin synovial fluid layer over the cartilage surfaces, mistargeting by the needle, and the complex foldings of the villi and discrete intraarticular synovial compartments that retain viscous occult synovial fluid [9,10,[21][22][23][24][25][26][27][28][29]36,37]. The present study demonstrates that external pneumatic compression of the noneffusive knee (Figure 1) mobilizes occult synovial fluid, dilates the joint space target with displaced occult fluid ( Figure 2) and permits fluid flow to the femoral condyles where the synovial fluid can be accessed using the anterolateral portal (Figure 3) [19,[37][38][39][40][41][42]. ...
Context 6
... despite pneumatic compression forcing synovial fluid from the suprapatellar bursa and superior knee to the femoral condyles where the fluid could be accessed, the fluid over the femoral condyle was layered quite thin dimensionally due to the restricted compressibility of adjacent fat pad (Figures 2 and 3). Thus, the needle often had to be rotated in the long axis so that the needle bevel was properly positioned in the fluid layer ( Figure 3). ...

Citations

... This increases the amount of SF available after inflation, and SF is under positive pressure. In a report by Iqbal et al. using non-image-guided aspiration in a flexed knee aspiration technique in patients without large effusions, they were able to increase the successful knee aspiration rate from 41% to 75% using a pneumatic thigh cuff inflated to 100 mmHg [33]. Therefore, our ability to aspirate ≥ 0.5 mL in 74% of our patients on their initial visit probably reflects the benefit of utilizing the US-guided needle visualization technique with external compression [34]. ...
Article
Full-text available
Background: Prior studies have demonstrated improved efficacy when intra-articular (IA) therapeutics are injected using ultrasound (US) guidance. The aim of this study was to determine if clinical improvement in pain and function after IA hyaluronic acid injections using US is associated with changes in SF volumes and biomarker proteins at 3 months. Methods: 49 subjects with symptomatic knee OA, BMI < 40, and KL radiographic grade II or III participated. Subjects with adequate aspirated synovial fluid (SF) volumes received two US-guided IA-HA injections of HYADD4 (24 mg/3 mL) 7 days apart. Clinical evaluations at 3, 6, and 12 months included WOMAC, VAS, PCS scores, 6 MWD, and US-measured SF depth. SF and blood were collected at 3 months and analyzed for four serum OA biomarkers and fifteen SF proteins. Results: Statistical differences were observed at 3, 6, and 12 months compared to baseline values, with improvements at 12 months for WOMAC scores (50%), VAS (54%), and PCS scores (24%). MMP10 levels were lower at 3 months without changes in SF volumes, serum levels of C2C, COMP, HA, CPII, or SF levels of IL-1 ra, IL-4, 6, 7, 8, 15, 18, ILGFBP-1, 3, and MMP 1, 2, 3, 8, 9. Baseline clinical features or SF biomarker protein levels did not predict responsiveness at 3 months. Conclusions: Clinical improvements were observed at 12 months using US needle guidance for IA HA, whereas only one SF protein biomarker protein was different at 3 months. Larger studies are needed to identify which SF biomarkers will predict which individual OA patients will receive the greatest benefit from IA therapeutics.
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