Typical needle-shaped calcium oxalate monohydrate (COM) crystals in the urine during ethylene glycol poisoning (a) (Regular HE-staining). Envelope-shaped calcium oxalate dihydrate crystals (b) are less frequent but may occur in early stages of poisoning (Polarized light) [4]

Contexts in source publication

Context 1

... mechanisms for the toxicity of ethylene glycol are not completely resolved. The role of oxalate (see Fig. 1) was originally based on the visualization of oxalate-like crystals in the urine (see Fig. 2a, b) and the development of acute renal failure. Later, it was suggested that the aldehyde metabolites -mainly glycolaldehyde -were responsible for the toxic syndrome. It has been shown experimentally that these aldehydes were able to inhibit oxidative phosphorylation, glucose metabolism, protein synthesis, DNA replication, and RNA ...

Context 2

... microscopy may reveal envelope-shaped calcium oxalate dihydrate crystals (typically in early stage) or needle-shaped calcium oxalate monohydrate crystals (typically in late stages) ( Fig. 2a, b). These findings may be delayed, and a negative microscopy should be repeated if diagnosis is still unclear. About half of patients present with crystalluria on admission, and most, but not all, develop this sign later. The crystalluria may be massive and easy to detect, even by an inexperienced microscopist. In addition, there usually ...