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Two large ring enhancing lesions at frontal lobe

Two large ring enhancing lesions at frontal lobe

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Fig. 2 Serial CT brain performed in November 2017 (a), January 2018 (b)...
Fig. 3 Two large ring enhancing lesions at frontal lobe
Fig. 4 a ZN stain showing absence of acid fast bacilli; b periodic acid...
Multiple ring enhancing lesions suggestive of tuberculoma
Case Report: Central Nervous System Tuberculosis Immune Reconstitution Inflammatory Syndrome in a Non-HIV Patient
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  • Jun 2020
Tuberculosis immune reconstitution inflammatory syndrome (TB-IRIS) is an abnormal, excessive immune response against live or dead Mycobacteria tuberculosis that may occur during or even after completion of anti-TB therapy, commonly in HIV-infected patients. However, this has also been reported amongst HIV negative patients. We report a case of CNS...
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... (Fig. 2). During the period of treatment, he remained asymptomatic. In December 2018, he presented again with left sided body weakness which was progressively worsening over 5 days with facial asymmetry and slurred speech. A repeat MRI brain showed 2 large frontal ring enhancing lesions and lesions in cerebellar hemispheres and vermis region (Fig. 3). Right frontal craniotomy and excision biopsy of right frontal lesion were performed. Intraoperative cerebrospinal fluid (CSF) for AFB was 3+, and the GeneXpert was positive for Mycobacterium tuberculosis complex with no rifampicin resistance detected. However, his CSF TB culture was negative. Histopathology examination (HPE) of the ...
Context 2
... (Fig. 2). During the period of treatment, he remained asymptomatic. In December 2018, he presented again with left sided body weakness which was progressively worsening over 5 days with facial asymmetry and slurred speech. A repeat MRI brain showed 2 large frontal ring enhancing lesions and lesions in cerebellar hemispheres and vermis region (Fig. 3). Right frontal craniotomy and excision biopsy of right frontal lesion were performed. Intraoperative cerebrospinal fluid (CSF) for AFB was 3+, and the GeneXpert was positive for Mycobacterium tuberculosis complex with no rifampicin resistance detected. However, his CSF TB culture was negative. Histopathology examination (HPE) of the ...

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Fatal Central Nervous System Co-Infection with SARS-CoV-2 and Tuberculosis in a Healthy Child
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  • Jun 2020
Background. Central and peripheral nervous system symptoms and complications are being increasingly recognized among individuals with pandemic SARS-CoV-2 infections, but actual detection of the virus or its RNA in the central nervous system has rarely been sought or demonstrated. Severe or fatal illnesses are attributed to SARS-CoV-2, generally wit...
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