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![Tuberous sclerosis complex. (a) Hyperintense cortical tubers in the subcortical white matter with associated with radial bands (arrows) on coronal FLAIR. (b, c) Different patient with tuberous sclerosis. (b) Subependymal periventricular nodule (note signal void representing calcification on axial SWI [susceptibility weighted image]). (c) Enhancing (left greater than right) subependymal giant cell astrocytomas (arrow points to left SEGA on axial postcontrast T1W MP-RAGE [magnetization-prepared rapid acquisitive gradient echo] image). SEGA, subependymal giant cell astrocytoma.](publication/362880401/figure/fig2/AS:11431281121847931@1677088810887/Tuberous-sclerosis-complex-a-Hyperintense-cortical-tubers-in-the-subcortical-white.png)
Tuberous sclerosis complex. (a) Hyperintense cortical tubers in the subcortical white matter with associated with radial bands (arrows) on coronal FLAIR. (b, c) Different patient with tuberous sclerosis. (b) Subependymal periventricular nodule (note signal void representing calcification on axial SWI [susceptibility weighted image]). (c) Enhancing (left greater than right) subependymal giant cell astrocytomas (arrow points to left SEGA on axial postcontrast T1W MP-RAGE [magnetization-prepared rapid acquisitive gradient echo] image). SEGA, subependymal giant cell astrocytoma.
Source publication
Dramatic changes have occurred recently in the field of epilepsy, including a fundamental shift in the etiology of epileptogenic substrates found at surgery. Hippocampal sclerosis is no longer the most common etiology found at epilepsy surgery and this decrease has been associated with an increase in the incidence of focal cortical dysplasia and en...
Context in source publication
Context 1
... sclerosis complex (TSC) is a rare, autosomal-dominant neurocutaneous disorder resulting from TSC1 and TSC2 mTOR pathway genes leading to excessive cell proliferation and hamartomatous lesions in various organs and systems. 55 CNS findings are characterized by multiple cortical tubers, subependymal nodules, subependymal giant cell astrocytoma (SEGA), and white matter lesions (Figure 8). Lessfrequent CNS findings include cerebral or cerebellar malformations, hemimegaloencephaly, and vascular abnormalities. ...
Citations
... Other entities with subtle imaging findings such as temporal lobe encephaloceles and autoimmune encephalitis could be included as potential differential diagnosis [7] . As our patient was young, malformations of cortical development including cortical dysplasia, polymicrogyria, and heterotopias could be alternative causes for the convulsive condition and detected by the MRI [7] . ...
... Other entities with subtle imaging findings such as temporal lobe encephaloceles and autoimmune encephalitis could be included as potential differential diagnosis [7] . As our patient was young, malformations of cortical development including cortical dysplasia, polymicrogyria, and heterotopias could be alternative causes for the convulsive condition and detected by the MRI [7] . ...
Tuberculomas are rare and a life-threatening condition. Diagnosis followed by appropriate treatment can lead to complete resolution of the disease. A suggestive imaging study in an appropriate clinical setting can lead to the diagnosis. We describe a case of a postpartum woman with a headache and seizure in which eclampsia was the initial suspicion. Imaging exams demonstrated a solitary expansile lesion in the left parietal lobe suspicious of neoplasia. A biopsy, instead, confirmed a tuberculoma. In addition to eclampsia, many other differential diagnoses are possible in the context of seizures in pregnant and peripartum patients, including central nervous system tuberculosis. Brain imaging studies can be crucial in the diagnostic process.
