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Situs inversus is a rare hereditary disorder in which various anomalies have been reported with internal rotation abnormalities. This case involved an 85-year-old woman who had been diagnosed with transverse colon cancer and who underwent reduced-port laparoscopic surgery. All intra-abdominal organs were reversed left to right and right to left. Th...
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Context 1
... first assistant was po- sitioned on the left side. A 4-cm-sized transverse incision, includ- ing the umbilicus, was done, and a single-port device (Octoport, Dalim SurgNET, Seoul, Korea) was installed to establish a pneu- moperitoneum with an intraperitoneal pressure of up to 12 mmHg. A 5-mm trocar was placed 10 cm caudally from the um- bilicus (Fig. ...
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Objetivo:
Presentar dos casos de vesícula biliar siniestra así como una revisión de la literatura disponible en la actualidad.
Descripción de caso:
Caso 1. Masculino de 64 años con cuadro de dolor abdominal tipo cólico en hipocondrio derecho de dos horas de evolución que remite con analgesia no especificada. Se realiza ultrasonido abdominal superi...
Situs inversus totalis (SIT) is rare congenital anomaly characterized by an inversion of the thoracic and abdominal viscera that crates a mirror image. Recently, several laparoscopic operations have been reported in patients with SIT. We herein report the case of a 76-year-old woman with ascending colon cancer who received a laparoscopic right cole...
Citations
... Surgery might be challenging in patients with situs inversus. Especially, in patients undergoing cholecystectomy or colonic resection [6][7][8][9]. Accumulating data highlighted that minimally invasive approach improves outcomes of patients in comparison with open surgery. Further experiences are needed to improve quality of minimally invasive surgery, even in challenging cases. ...
Situs inversus (SI) is a rare congenital condition characterized by a mirror-image transposition of the major visceral organs. Since the 1990s, more than one hundred SI patients have been reported to have successfully undergone laparoscopic cholecystectomy. In these cases, the major problem is to overcome is the left-right condition for right-handed surgeons. Laparoscopic common bile duct exploration (LCBDE), an alternative to treat patients with bile duct stones, has shown equivalent efficacy and is less likely to cause pancreatitis than endoscopic retrograde cholangiopancreatography. Recent updated meta-analyses revealed that a shorter postoperative hospital stay, fewer procedural interventions, cost-effectiveness, a higher stone clearance rate, and fewer perioperative complications are additional advantages of LCBDE. However, the technique is technically demanding, even for skilled laparoscopic surgeons. Conducting LCBDE in patients with difficult situations, such as SI, is more complex than usual. We herein review published SI patients with choledocholithiasis treated by LCBDE, including our own experience, and this paper focuses on the technical aspects.
MicroRNA-129-3p plays a pro-cancer role in colorectal cancer by down-regulating BIM. This study intends to assess its role in colorectal cancer cells. A total of 30 colorectal cancers and 10 paracancerous samples were obtained to measure MicroRNA-129-3p expression by PCR. Colorectal cancer cells were transfected with miR-129-3p mimic or inhibitor followed by analysis of cell growth, apoptosis. miR-129-3p expression was significantly lower in colorectal cancer tissues than that in cancer adjacent tissues ( P <0.05). miR-129-3p overexpression after mimic transfection significantly inhibited cancer cell viability and promoted apoptosis ( P < 0.05). Moreover, it also significantly downregulated E2F5, BIM and FoxO3a in colorectal cancer cells. Furthermore, E2F5 was targeted by miR-129-3p. In conclusion, miR-129-3p inhibits colorectal cancer cell proliferation via targeting E2F5 to downregulate BIM, indicating that it might be a target for treating colorectal cancer.
Background
Situs inversus totalis (SIT) is a rare congenital malformation in which the viscera is positioned in the opposite direction of normal, like a mirror. The patients of SIT with colorectal cancer (CRC) requiring surgical treatment are even more rare.
Methods
From January 2013 to May 2022, the clinical data of 5 SIT patients with CRC diagnosed in the Sixth Affiliated Hospital of Sun Yat-sen University were reviewed.
Results
Five SIT patients with CRCwere all female, aged 53-76 years. One patient died of complications after surgery due to poor cardiopulmonary function; One patient presented with a recurrent lesion of the side of the urethra after surgery and was readmitted for chemoradiotherapy. One patient died of tumor recurrence after surgery and chemotherapy. One patient with IIA was indicated by pathology after operation, and no recurrence was found. No tumor recurrence was found in one patient with early pathological indication. After reviewing 17 related literatures, together with 5 cases in our hospital, the most common primary sites of tumors were the sigmoid node and ascending colon, and the median survival of patients with combined chemotherapy was longer.
Conclusions
It is safe and feasible to perform surgery on the SIT patients with CRC after the preoperative examination and evaluation.
Background:
Situs inversus totalis (SIT) is a rare group of congenital developmental malformations in the clinical setting, with all organs in the chest and abdomen existing in a mirror image reversal of their normal positions. Few reports have described laparoscopic surgery for colorectal cancer in patients with SIT, and it is considered difficult even for an experienced surgeon because of the mirror positioning. We present a case report of laparoscopic radical resection of a colonic splenic flexure carcinoma in a patient with SIT.
Case summary:
A 72-year-old male was referred to our hospital with colonic splenic flexure carcinoma, and computed tomography showed that all the organs in the chest and abdomen were inverted. Laparoscopic hemicolectomy with complete mesocolic excision was safely performed. The operating surgeon stood on the patient's left side, which is opposite of the normal location.
Conclusion:
Abdominal computed tomography is an effective method for diagnosing SIT preoperatively in patients with colonic splenic flexure carcinomas. Laparoscopic radical resection is difficult, but it is well established and safe. The surgeon should stand in the opposite position and perform backhand operations.
