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Transcranial doppler waveform of middle cerebral artery from a patient with acute liver failure. Under normal circumstances, the first peak is related to myocardial contractility and the second peak is produced by the distensibility of the arterial wall (asterisk indicates diastolic vascular recoil). As intracranial pressure increases, peak systolic velocity increases and wave becomes sharpened due to external compression of the artery. The second peak becomes reduced due to the reduced compliance of the artery and finally disappeared (loss of Windkessel effect).
Source publication
Early diagnosis and management of cerebral edema in acute liver failure is important to reduce neurological complication and mortality. Ammonia-induced astrocyte swelling and increased blood brain barrier permeability via transmembrane dysfunction are major mechanisms of cerebral edema in acute liver failure. Conventional therapy can be used to low...
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Background
Acute liver failure (ALF) is a critical illness with a large number of viral and nonviral causes. Clinical course and etiologies in the Asian countries are different from those reported from the Western world and mortality is high. There may even be intracountry variations in large countries like India, which have differing culture, ethn...
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The complement system plays an important role in innate immunity inducing liver diseases as well as signaling immune cell activation in local inflammation regulating immunomodulatory effects such as liver damage and/or liver regeneration. Our aim is to evaluate the role of complement components in acute liver failure (ALF) caused by viral hepatitis...
Regorafenib is a multikinase inhibitor which showed benefits in pretreated metastatic colorectal cancer patients. Hepatotoxicity has been described as a frequent side effect. We report the case of a 65-year-old patient presenting with jaundice, fever, and hepatocellular insufficiency which led to death of the patient. She had previously been treate...
