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Cardiovascular diseases (CVD) are the leading cause of death all over the world. Beside general risk fac�tors, there are some genetic factors which lead to cardiovascular diseases. Various nuclear DNA mutation
and also mitochondrial DNA mutations have been related with cardiovascular diseases. In the present
study, a total of 21 samples were collec...
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Context 1
... the collected samples were processed for DNA extraction in which we get results of only 10 samples as shown in Fig. ...
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... and sisters were also suffering from heart disease. The weight of the patient was 65 Kg and was diagnosed with other diseases such as, skin allergy problem, kidney problem, eye problem, mouth allergy. The patient was using low plat plus (75 mg), concor (5 mg), nitromint (5 mg) tablets. No mutation was present in leu-tRNA gene of this subject (see Fig. ...
Citations
... The scores from MitoTIP and PON-mt-tRNA analysis were compared to determine the pathogenicity levels of variants identified in the present study (Table III). All four variants were found to be deleterious up to different levels (Din et al., 2021;Fu et al., 2021). RMSD (root mean square deviation) based comparison of normal and mutant tRNA genes by structural alignment analysis has shown significant structural differences between the normal and variant tRNA genes (Figs. 3, 4, and Table IV (Meng et al., 2021). ...
... The scores from MitoTIP and PON-mt-tRNA analysis were compared to determine the pathogenicity levels of variants identified in the present study (Table III). All four variants were found to be deleterious up to different levels (Din et al., 2021;Fu et al., 2021). RMSD (root mean square deviation) based comparison of normal and mutant tRNA genes by structural alignment analysis has shown significant structural differences between the normal and variant tRNA genes (Figs. 3, 4, and Table IV (Meng et al., 2021). ...
The association of airborne particulate matter exposure with the deteriorating function of the cardiovascular
system is fundamentally driven by the impairment of mitochondrial-nuclear crosstalk orchestrated by aberrant
redox signaling. The loss of delicate balance in retrograde communication from mitochondria to the nucleus
often culminates in the methylation of the newly synthesized strand of mitochondrial DNA (mtDNA) through
DNA methyl transferases. In highly metabolic active tissues such as the heart, mtDNA’s methylation state
alteration impacts mitochondrial bioenergetics. It affects transcriptional regulatory processes involved in
biogenesis, fission, and fusion, often accompanied by the integrated stress response. Previous studies have
demonstrated a paradoxical role of mtDNA methylation in cardiovascular pathologies linked to air pollution. A
pronounced alteration in mtDNA methylation contributes to systemic inflammation, an etiological determinant
for several co-morbidities, including vascular endothelial dysfunction and myocardial injury. In the current
article, we evaluate the state of evidence and examine the considerable promise of using cell-free circulating
methylated mtDNA as a predictive biomarker to reduce the more significant burden of ambient air pollution on
cardiovascular diseases.
