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Topical Antifungal Therapy for Dermatophytoses and Pityriasis Versicolor

Topical Antifungal Therapy for Dermatophytoses and Pityriasis Versicolor

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Tinea capitis, tinea corporis, and pityriasis versicolor are common superficial fungal infections in the pediatric population. • Tinea capitis is the most common dermatophyte infection worldwide. In North America, the cause is almost exclusively T tonsurans. Diagnosis of tinea capitis usually can be made by clinical features alone, especially when...

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... have broad antifungal activity against dermatophytes, Malassezia, Candida, and Gram- positive bacteria. A few agents in this class are formulated for once-daily application ( Table 6). ...

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... Tinea pedis, a dermatophytosis of the feet caused primarily by the fungal pathogens of the Trichophyton and Epidermophyton genera, represents a significant dermatological concern in the adolescent demographic [1][2][3]. Tinea pedis in prepuberal children is rare, but in adolescents, due to their specific lifestyle and physiological characteristics, are predisposed to this fungal infection. In this review, we provide an in-depth exploration of tinea pedis in adolescents, considering that underscore its clinical presentation and management [3][4][5]. ...
... Tinea pedis in prepuberal children is rare, but in adolescents, due to their specific lifestyle and physiological characteristics, are predisposed to this fungal infection. In this review, we provide an in-depth exploration of tinea pedis in adolescents, considering that underscore its clinical presentation and management [3][4][5]. ...
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Purpose of Review The purpose of the review is to provide a detailed overview of athlete’s foot (tinea pedis) in adolescents, covering its causes, symptoms, diagnosis, treatment, and prevention. Recent Findings Research on adolescent athlete’s foot (tinea pedis) reveals its higher prevalence in developed countries during the summer due to communal environments and sports activities. Diagnosis methods include dermoscopy and molecular techniques, while treatment options range from topical to systemic antifungal agents. Preventive measures emphasize foot hygiene and adolescent awareness. Summary Tinea pedis, commonly known as athlete’s foot, is a dermatophytic fungal infection that predominantly affects the skin of the feet. This condition is particularly prevalent among adolescents, presenting both clinical and public health significance. In this comprehensive review, we aim to elucidate the epidemiology, risk factors, clinical manifestations, diagnostic modalities, treatment options, and preventive measures associated with tinea pedis in the adolescent population.
... Multiple lesions gather to form polycyclic patterns. 7 Ayurveda classifies all skin diseases as 'Kushtha,' which is further subdivided into two types: Mahakushtha (major skin disorders) and Kshudrakushtha (minor skin disorders). Dadru (Tinea corporis) is one of them. ...
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Background Skin disorders are often seen as a result of a change in lifestyle, a lack of physical activity, and inadequate nutrition. Hygiene, emotional stress, and poor eating habits are also factors to consider. Kushta is the term used in Ayurveda to describe all skin disorders which is classified as Mahakushtha (major skin disorders) and Kshudrakushtha (minor skin disorders) . Dadrukushta is a type of kshudrakushta that is commonly seen in clinical practice. In Ayurveda, the signs of dadrukushta are same as those of Tinea corporis, which is explained in modern science. Tinea corporis has a wide range of clinical symptoms that are mostly dependent on the infective organisms. By treating the condition with Ayurveda’s treatment therapy produces long term Outcomes. Aim & Objectives Aim of this contemporary study was to assess how Ayurvedic modality shamana chikitsa works on Dadrukushta. Case A 27 year old male patient approached to Kayachikitsa OPD with complaints of blackish lesions with raised borders and itching over the chest and back (upper) region for 15 days having disturbed sleep which undergone treatment of shamanachikitsa (palliative care). Dadrukushta (Tinea corporis) can be dealt with shamana karma (palliative care) using internally Gandhakrasayan (Moringa ovalifolia prepared from sulphur), Panchtiktaghrita (Pancha means five, Tikta means bitter in taste. Tikta Rasapradhan Dravyas are collectively called as Panchatikta Dravyas. The five Dravyas are Azadirachta indica (Neem), Trichosanthes dioica (Patola), Solanum xanthocarpum (Kantakari), Tinofpora cordifolia (Guduchi) and Adhatoda vasica (Adulsa), fungiwin cream, Karanjataila (Pongamia pinnata oil tree) , S-kin powder for local application for 45 days. Results The Gradation Score was 8 before treatment, after 45 days it was 0. The patient in this case study experienced relief in the symptoms. Conclusions The patient obtained better results by Shamanachikitsa.
... Vulvovaginal Candidiasis (VVC), often called vaginal thrush, is a gynaecological disorder caused by Candida albicans overgrowth in the vagina. 1,2 Candida albicans, is a pathogenic fungus that caused VVC in over 85% of cases. 3 Fluconazole (FCZ) ( Figure 1) is a widely prescribed first-line medicine that belongs to the azole chemical class. ...
... In the course of time more than 69.000 species of fungi have been described while it has been estimated that the total number of fungal species is of the order of 1.5 million 1 . The term "superficial fungal infections" refers to infections brought on by pathogenic fungus that are limited to the human hair, nails, epidermis, and mucosa (the study of pathogenic fungi that cause diseases in humans is called medical mycology) 2 . On the skin's surface, particularly in the body's moist regions, healthy fungi can be found. ...
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... It is prevalent in developing nations. Tinea corporis, tinea capitis, tinea pedis, tinea cruises, and pityriasis vesicular are the most common fungal infections [11]. Tinea corporis is more prevalent in children and young adults and infects the whole body. ...
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Skin is the outer cover of our body, which protects vital organs from harm. This important body part is often affected by a series of infections caused by fungus, bacteria, viruses, allergies, and dust. Millions of people suffer from skin diseases. It is one of the common causes of infection in sub-Saharan Africa. Skin disease can also be the cause of stigma and discrimination. Early and accurate diagnosis of skin disease can be vital for effective treatment. Laser and photonics-based technologies are used for the diagnosis of skin disease. These technologies are expensive and not affordable, especially for resource-limited countries like Ethiopia. Hence, image-based methods can be effective in reducing cost and time. There are previous studies on image-based diagnosis for skin disease. However, there are few scientific studies on tinea pedis and tinea corporis. In this study, the convolution neural network (CNN) has been used to classify fungal skin disease. The classification was carried out on the four most common fungal skin diseases: tinea pedis, tinea capitis, tinea corporis, and tinea unguium. The dataset consisted of a total of 407 fungal skin lesions collected from Dr. Gerbi Medium Clinic, Jimma, Ethiopia. Normalization of image size, conversion of RGB to grayscale, and balancing the intensity of the image have been carried out. Images were normalized to three sizes: 120 × 120, 150 × 150, and 224 × 224. Then, augmentation was applied. The developed model classified the four common fungal skin diseases with 93.3% accuracy. Comparisons were made with similar CNN architectures: MobileNetV2 and ResNet 50, and the proposed model was superior to both. This study may be an important addition to the very limited work on the detection of fungal skin disease. It can be used to build an automated image-based screening system for dermatology at an initial stage.
... Globally, T. rubrum stands out as the predominant cause of dermatophytosis. (12) Tinea corporis resulting from tinea capitis is frequently attributed T. tonsurans [13] Patients who have contact with cats or dogs are commonly infected with Microsporum canis. Tinea corporis gladiatorum can present in athletes particularly wrestlers who have direct skin contact [14] . ...
... albicans, C tropicalis, C. krusei, C. parapsilosis) have been identified as prevalent causal organisms for fungal infections. [1][2] Although various antifungal dosage forms and treatments are approved and available for the management of superficial infections, the ability of antifungal drugs is dependent on several factors, including the ability of the drug to transmit through the stratum corneum, the skin's outermost layer, its molecular mass and concentration, and the ability to achieve therapeutic drug concentration levels in the skin. [3][4][5] Miconazole nitrate chemically denoted as (RS)-1-[2-(2,4-Ichlorophenylmethoxy)2-(2,4-dichlorophenyl) ethyl]-1H-imidazole nitrate, is a drug with poor oral absorption and is very slightly soluble in waterwhich limits its efficacy and bioavailability in various dosage forms. ...
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Antecedentes: la Tiña de la Cabeza o Tiña Capitis es una enfermedad propia y casi exclusiva de la infancia causada por alguna de las especies de dermatofitos usualmente de los géneros Microsporum y Trichophyton. Temática: entre los factores de riesgo asociados a la primoinfección está el uso de equipos de peluquería contaminados con los microorganismos, el contacto con animales o bien, directamente de persona a persona. El dato clínico más relevante es la aparición de una o varias placas alopécicas o pseudoalopécicas con pelos cortos y rotos, eritema, descamación y ocasionalmente la presencia de pápulas y pústulas. Metodos: revisión narrativa. Se identificaron artículos de las bases de datos ScienceDirect, Scopus, PubMed, MEDLINE y Google Scholar, publicados entre 1982 y 2021 que tuvieran en el título los términos, tiña capitis, dermatomicosis en niños, antifúngicos en niños, niños, diagnóstico de Tinea capitis, epidemiología y dermatomicosis, utilizando los conectores «AND» y «OR». Esta revisión se llevó a cabo durante un período de seis meses desde agosto de 2021 hasta enero de 2022. Resultados: la evolución de la infección puede afectar la calidad de vida de los pacientes, por lo que se vuelve imprescindible la confirmación microbiológica que permita un tratamiento adecuado. Conclusión: el manejo debe ser con medicamentos vía oral por lo menos durante cuatro semanas y entre los fármacos utilizados se encuentra la griseofulvina, terbinafina e itraconazol.
... Tinea capitis can be caused by a variety of species, such as zoophilic, geophilic, or anthropophilic, all of which can affect the skin of the head [1]. Ninety-five percent of cases in North American countries are caused by Trichophyton species, mainly Trichophyton tonsurans [2]. Meanwhile, in Europe, Microsporum canis has remained the most common pathogenic species for tinea capitis until now. ...
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Background Tinea capitis is the most common dermatophytosis in children. Due to many factors, the types of pathogenic fungi of tinea capitis vary all over the world, and the pathogenic fungi of tinea capitis may change over time even in the same region. Objectives To investigated the epidemiological characteristics and pathogenic strains distribution of tinea capitis in children in Beijing and adjacent regions. Patients/Methods Through retrospective study and epidemiological analysis, we investigated the epidemiological characteristics of tinea capitis in children in Beijing and adjacent regions over 15 years. Results A total of 1739 children with tinea capitis were retrospectively investigated from January 2006 to December 2020, including 1100 boys and 639 girls. A total of 67.4% of tinea capitis patients were between 1 and 5 years of age. A decreasing trend in tinea capitis was observed before 2009, while for the following 12 years, the incidence rate of tinea capitis fluctuated little. Zoophilic isolates (primarily Microsporum canis) were responsible for 88.4% of tinea capitis. Males are at greater risk for M. canis infection (p = 0.02). Conclusion Zoophilic species were responsible for approximately nine-tenth of the tinea capitis cases. The incidence of tinea capitis decreased before 2009.
... Superficial fungal infections came from both dermatophytes genera (Microsporum, Trichophyton, and Epidermophyton) and non-dermatophytes (pityriasis versicolor, cutaneous candidiasis, tinea nigra, black piedra, and white piedra). 1 Dermatophyte relies on keratin, a protein found in skin, hair, and nails. 2 Tinea infections are named after the latin names of the anatomical sites of infection, such as tinea capitis (scalp), tinea corporis (body), tinea manuum (hand), tinea cruris (groin), tinea pedis (foot) and tinea unguinum (onychomycosis) (nail). 3 According to a couple studies, the disease affects roughly 20% to 25% of people worldwide. ...
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Background: Superficial fungal infection is a common skin disease among children, causing morbidity and reducing quality of life. The disease's prevalence and etiological agents change with geographic area, age, humidity, and sex. The data on this matter is still limited in Indonesia. Purpose: To determine the current epidemiologic and sociodemographic features of superficial fungal infection among children. Methods: This descriptive study examined all the pediatric inpatients and outpatients at the Department of Dermatology and Venerology of East Java suburban Public Hospital in Indonesia from 2016 to 2020 who met the inclusion criteria. Result: From 2016 to 2020, the number of fungal infection patients was 12.3% (n = 175) among 1,427 dermatology patients. Pityriasis versicolor (PVC) is the most common fungal skin disease (4.1%), followed by tinea capitis (2.2%), tinea cruris (1.6%), and tinea corporis (1.4%). Subjects aged 6 to 12 years old were the most likely to be infected with a fungus. Boys were more likely to develop this infection. Conclusion: From 2017 to 2020, there was a downward trend in children's superficial fungal infections. Pityriasis versicolor (PVC) is a fungal skin ailment that cause the most cases compared to other fungal infections. Boys and children between the ages of 6 to 12 years old were the most susceptible to fungal infection.