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In this paper, an overview of Amperomet-ric Biosensors with application to chemical measurement systems is presented first. We then focus on signal processing enhancement of emerging Amperomet-ric Biosensors suitable for eHealth applications by design and implementation of an analog four-path high-quality Band Pass Filter (BPF) with adjustable cent...
Citations
... The electrochemical properties of the transducer determine the properties of the biosensors, which are generally called electrochemical biosensors [12]. There are several methods of detection like amperometric [13,14], potentiometric [15] or impedimetric biosensors [16]. Generally, amperometric is employed owing to its robustness, ease of miniaturization, and minimal sample requirement. ...
Biosensors have emerged as a potential tool for selective and sensitive detection. Biomolecules like enzymes, deoxyribonucleic acid (DNA), and antibodies are used as recognition sites in biosensors due to their high selectivity, sensitivity, and signal-to-noise ratio. Nowadays, biosensors are used to detect many vital biomolecules such as glucose, urea, and cholesterol. Exploiting enzymes for the selective detection of target molecules are very good but may not be easily accomplished as enzymes often need to be immobilized onto support materials, which requests either modifying the surface or using appropriate linkers to synthesize biosensors. Currently, many biosensors’ signal strength and stability still are low, which encourages the fabrication of functionalized nanomaterials/nanoparticles to enhance electrochemical performance. The review covers current progress in modifying enzyme immobilized biosensors to detect biologically essential molecules (glucose, urea, cholesterol). A discussion of the different types of enzyme immobilization is also provided. This review may be helpful for researchers to build rational and novel biosensors for efficient enzyme immobilization and sensing applications.
As one of the most important biological fluids, whole blood provides important information for health management and disease monitoring. Ions are an important component of blood and carry key information for early diagnosis of diseases. Therefore, a highly selective, sensitive, accurate, and reliable technology is needed to detect the ion content in blood to monitor the health status. Among them, electrochemical biosensors are famous for their advantages in detecting ions in blood, such as quickness, sensitivity, reagent-free, and cleaning-free. In order to achieve the sensitivity and selectivity of blood analysis, electrochemical biosensors have explored many strategies, including the use of hierarchical electrodes, nanomaterial modification, and enzyme amplification. Here, we aim to comprehensively review all these advances, challenges, and opportunities in electrochemical biosensors for the detection of ions in blood.
