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This model suggests that memory consolidation during sleep entails a constant dialogue between hippocampus and the neocortex. Image credit: Reprinted with permission from Reference 2.
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... However, little is known about molecular markers for sleep phases. It has been suggested that the protein Cacna2d1 participates in the transition from NREM to REM sleep [31]. This protein may favor the calcium flow present in NREM. ...
Memory consolidation related to the hippocampal-cortex connection takes place during sleep. This connection may involve at least two steps— one in the NREM phase of sleep (transmission) and the other in the REM phase (consolidation). In this brief report, we comment on the role of tau protein in these two phases of sleep. The absence of tau decreases δ waves in NREM, whereas the overexpression of modified (phosphorylated and/or mutated) tau alters θ waves in REM.
