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Source publication
To evaluate histopathologic properties of eyelid skin and conjunctiva and the association between clinical manifestation and histopathologic findings.
Similar publications
Purpose
To explore a new classification scheme for acute ocular burns.
Methods
Medical records of 345 patients (450 eyes) with acute ocular burns treated at Shandong Eye Institute between January 2013 and January 2018 with a 12-month minimum follow-up were retrospectively reviewed. A total of 8 parameters in the acute phase were evaluated and grad...
Citations
... Park et al [20] Bae and Park [22] 2013 Korea Dilated lymphatic vessels, decreased goblet cell and collagen densities, degeneration of elastic fibers H&E staining, VVG elastic staining 14, no control Dong et al [23] 2014 China S q u a m o u s e p i t h e l i a l h y p e r p l a s i a , s l i g h t hyperkeratosis of some superficial cells, pigment calm of basal cells, lamina propria vascular congestion and expansion, interstitial infiltration of lymphoid and plasma cells H&E staining 20 patients and 22 control K a n t a p u t r a e t al [24] 2014 Thailand Hyperplasia of the conjunctival epithelium with subepithelial conjunctival mononuclear inflammatory cell infiltration, very few blood vessels with abnormal elastic fiber Silver staining 1, no control Yu et al [25] 2015 China Obvious squamous epithelial hyperplasia, parakeratosis, basal cell pigmentation, lamina propria hemorrhage, infiltration of lymphocytes, and reduction of elastic fibers and collagen fibers H&E staining, Masson's trichrome staining 83, no control logical form of analogical reasoning is: A object and B object have attributes: a 1 , a 2 , …, a n ; A object yet has attributes: a n+1 ; So, B object also has attributes: a n+1 . Cutis laxa (CL) is characterized by a loose, redundant, hypoelastic skin. ...
The PubMed, MEDLINE databases and China National Knowledge Infrastructure (CNKI) were searched for information regarding the etiology and pathogenesis of conjunctivochalasis (CCh) and the synthesis and degradation of elastic fibers. After analysis of the literature, we found elastic fibers was a complex protein molecule from the structure and composition; the degradation of elastic fibers was one of the histopathological features of the disease; the vast majority of the factors related to the pathogenesis of CCh ultimately pointed to abnormal elastic fibers. By reasonably speculating, we considered that abnormal elastic fibers cause the conjunctival relaxation. In conclusion, we hypothesize that elastic fibers play an important role in the pathogenesis of CCh. Studies on the mechanism of synthesis, degradation of elastic fibers are helpful to clarify the pathogenesis of the disease and to find effective treatment methods.
... [3][4][5][6] Dermatochalasis causes differences in biomechanical properties of the skin, and histologic samples of the connective tissue show related alterations in the skin and the ocular surface of patients with this condition. 7,8 However, a gap exists in the evaluation of biomechanical properties of the cornea -a major optical tissue of anterior segment -in dermatochalasis patients. In this study, we examined the corneal biomechanical alterations associated with dermatochalasis. ...
Purpose
The aim of this study was to investigate the possibility of a relationship between corneal biomechanical properties and different grades of dermatochalasis.
Patients and methods
Patients were assigned to four groups according to the severity of their dermatochalasis: normal (Group 1), mild (Group 2), moderate (Group 3), and severe (Group 4). An Ocular Response Analyzer device was used to measure corneal hysteresis (CH), corneal resistance factor (CRF), and corneal-compensated intraocular pressure (IOPcc).
Results
We found no significant differences in the mean values of the CH, CRF, and IOPcc of all groups (P=0.75, P=0.93, and P=0.11, respectively). However, CH and IOPcc were negatively correlated in Group 1, Group 2, and Group 3 patients (P=0.013, r=−0.49; P=0.015, r=−0.52; and P=0.011, r=−0.47, respectively), but this correlation was not apparent in the Group 4 patients (P=0.57, r=0.12). CRF and IOPcc were correlated, but only in Group 4 (P=0.001, r=0.66).
Conclusion
Severe dermatochalasis was associated with altered corneal biomechanical properties. Some of the important visual consequences of dermatochalasis and related diseases (such as floppy eyelid syndrome) can be understood by considering corneal biomechanical alterations.
In this study we investigated the histopathologic characteristics of conjunctivochalasis and its association with lymphangiectasis using impression cytology and conjunctival excisional biopsy in patients with conjunctivochalasis.
