Figure 3 - uploaded by Irfan Mohamad
Content may be subject to copyright.
The tumour tissue shows neoplastic cells arranged in sheets. These cells are markedly pleomorphic with large, irregular vesicular nuclei and prominent large nucleoli. (H&E stain, 400x magnification).
Source publication
Carcinosarcoma is a rare type of malignant tumour that possess both the elements of carcinoma and sarcoma. They may occur in various locations such as the uterus, breast, thyroid, lung and gastrointestinal system. However, very few primary mediastinal carcinosarcomas have been reported. We are presenting a case of a 75-year-old male who presented w...
Contexts in source publication
Context 1
... cells show plasmacytoid appearance. Sprinkles of mature lymphocytes were seen in some areas (Figure 3). Immunohistochemical status were diffuse and strongly positive for CKAE 1&3 and vimentin. ...
Citations
... Carcinosarcoma is a rare malignancy that is defined as a biphasic tumor composed of epithelial (carcinomatous) and malignant heterologous mesenchymal (sarcomatous) components. 1 carcinosarcoma are most common in the uterus but also occur in other organs including lung. 2 Only rare carcinosarcoma have been documented in the mediastinum. [3][4][5][6][7][8] In the mediastinum, the tumor is presumed to originate from the thymus, or from the lung with invasive spread into mediastinum. Here we provide a detailed clinicopathological description of carcinosarcoma presenting within the mediastinum and showing unusual paraneoplastic and genetic profiles. ...
... Some of the prior tumors reported as carcinosarcoma would have been now classified as sarcomatoid carcinoma. [3][4][5][6] As a group these tumors appear to affect both sexes from 5th to 9th decades of life. The presenting symptoms are not specific and include chest pain and dyspnea. ...
Carcinosarcomas of mediastinum are rare and only few well-documented cases are available in the literature. We report a detailed description of mediastinal carcinosarcoma with unique clinical manifestations and immunohistochemical and molecular profiles. A 44-year-old female with an enlarging anterior mediastinal mass was found to have a positive pregnancy test. Thoracoscopic biopsy revealed that the mass represented a carcinosarcoma with adenocarcinoma and chondrosarcoma components. The tumor focally expressed beta-HCG by immunohistochemistry and had KRAS G12A missense mutation by next generation sequencing. The case documents a rare presentation of carcinosarcoma within the mediastinum with uncommon paraneoplastic syndrome and genetic profile. Awareness of these unusual clinical and pathological manifestations of the tumor will help in reaching correct diagnosis and proper management of such patients.
