Fig 2 - uploaded by Artem Piddubnyi
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The tumor of the small intestine (metastasis of MCC to small intestine). (А) -hematoxylin-eosin staining. IHC detection of (B) -CD45; (C) -S100; (D) -TTF1; (E) -CK pan; (F) -Chromogranin A; (G) -Synaptophysin; (H) -CK7; (I) -CK 20; (J) -Ki-67.
Source publication
Merkel cell carcinoma is a rare primary neuroendocrine malignant neoplasm of the skin, which recurs in about 40 % of cases. The main factors are Merkel cell polyomavirus (MCPyV) and mutations caused by ultraviolet radiation [Paulson, 2018]. In this study, we report a case of Merkel cell carcinoma with metastasis to the small intestine. In a 52-year...
Contexts in source publication
Context 1
... the other hand, the tumor was positive for markers of neuroendocrine tumors, such as Chromogranin A and Synaptophysin, and had a positive membrane dot-like reaction to CK 20. Ki-67 was expressed in 60-70 % of tumor cells (Fig. 2). All these results and clinical data pointed out for the recurrence of MCC in this ...
Context 2
... the other hand, the tumor was positive for markers of neuroendocrine tumors, such as Chromogranin A and Synaptophysin, and had a positive membrane dot-like reaction to CK 20. Ki-67 was expressed in 60-70 % of tumor cells (Fig. 2). All these results and clinical data pointed out for the recurrence of MCC in this ...
Citations
... Among the most exciting and widespread areas of publishing activity are the ways of metastasis of ovarian cancer because the process of metastasis in ovarian cancer differs from the model of hematogenous metastasis, which is characteristic of most cancers of other localizations [11]. The stages of intra-and extravasation characterize this model before the development of metastasis in one or another organ [12]. However, the metastatic process of ovarian cancer is somewhat more straightforward. ...
Introduction. Ovarian cancer is an oncogynecological disease with high mortality. High mortality caused by this pathology is associated with diagnosis at the III–IV stage of the disease. This stage of the disease is characterized by metastasis and reflected in the 5-year survival rate, decreasing to 30.2 %. At the same time, when diagnosed at the I-II stage, this indicator is 92.6%. The aim of the work is bibliometric analysis and generalization of data from scientific sources on the study of ovarian cancer metastasis. Materials and methods. Information was searched on electronic resources of the Scopus, Web of Science, PubMed, and Google Scholar databases using the keywords "ovarian cancer" and "metastases." An online platform for monitoring and analyzing scientific sources was used for bibliometric analysis. We used several VOSviewer bibliometric network visualization system tools and SciVal (Scopus) modern citation requirements. Results. It has been established that metastasis of ovarian cancer can occur in several ways and depends on the conditions of the tumor microenvironment. The influence of E-cadherin, MMP-2, and transglutaminase-2 on metastasis processes was evaluated. Also, the role of cytokines in the invasiveness of the tumor process and metastasis was established. The results of bibliometric analysis of scientific sources showed that over the past 20 years, the number of publications on ovarian cancer metastasis has increased significantly, and the most widely given topic is studied in the USA and China. Conclusions. Metastasis of ovarian cancer can occur in several ways and depends on the conditions of the tumor microenvironment. It was found that among the analyzed 496 publications, the most relevant directions are molecular-biological and signaling pathways, which are described in many ways in scientific sources on ovarian cancer metastasis. The calcification of peritoneal metastases and their formation mechanism are currently not investigated, and there is no thorough explanation that may become a perspective for further research.
