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... effect of time on the absorbance of the colored Schiff base product was studied with different time periods. The absorbance of the resulting compound against the blank solution was measured at the wavelength of 447 nm by adding two different concentrations of 10 and 20 µg of MCPD at the final volume of 5 ml (see Table 7). It is noted from the results proven in Table 7 that the Schiff base product is stable after about 10 minutes and remains stable for 50 minutes. ...Context 2
... absorbance of the resulting compound against the blank solution was measured at the wavelength of 447 nm by adding two different concentrations of 10 and 20 µg of MCPD at the final volume of 5 ml (see Table 7). It is noted from the results proven in Table 7 that the Schiff base product is stable after about 10 minutes and remains stable for 50 minutes. Therefore, this time of 10 minutes was adopted in the subsequent experiments. ...Similar publications
Knowledge of drug solubility data in supercritical carbon dioxide (SC-CO2) is a fundamental step in producing nano and microparticles through supercritical fluid technology. In this work, for the first time, the solubility of metoclopramide hydrochloride (MCP) in SC-CO2 was measured in pressure and temperature range of 12 to 27 MPa and 308 to 338 K...
Citations
... Along with other spectrophotometric techniques, including oxidative-coupling reactions [14][15][16], oxidation-reduction reactions [17], charge transfer complexes [18], ion-pair complexes [19], Schiff's bases [20,21], complexes after oxidation of metoclopramide [22,23], UV method [24], and interaction between the amino groups in MCPD and 1,2-naphthoquinone [25]. Numerous additional methods, including HPLC [26], LC-MS [27], LC-MS/MS [28], flow injection [29], electrochemiluminescence [30]and capillary electrophoresis [31], volumetric oxidation [ 32], potentiometric sensor [33], molar refraction and polarizability [34], atomic absorption [35], quenched continuous fluorescence [36] and spectrofluorometric [37]., have also been employed to assess MCPD. ...
For the determination of metoclopramide hydrochloride (MCPD) in pharmaceutical formulations, a rapid and straightforward spectrophotometric method has been proposed. The method involves diazotizing the main amino group of MCPD with sodium nitrite followed by coupling reaction with reagent 1,7-Dihydroxynaphthalene (1,7-DHN) to form a stable and colored compound in alkaline medium of sodium hydroxide which showed a maximum absorbance intensity at the wavelength 578 nm. The linearity of developed method has ranged from 1.0 - 15 µg.ml-1 while the molar absorptivity 2.9867x104 l.mol-1.cm-1, RSD% was less than 1.11%. While the LOD and LOQ were 0.059 µg.ml-1 and 0.198 µg.ml-1 respectively. The method is appropriate for the determination of MCPD in the presence of other substances that are typically included in dosage forms.
... There are many different techniques that have been used for the determination of metoclopramide by various methods, including spectrophotometric methods [6,15], HPLC [16][17][18][19][20][21], potentiometric [22], Densitometric and UPLC methods [23], fluorometric [24], Flow Injection Chemiluminescence Technique [25], voltammetric [26], electrochemiluminescence [27],Capillary electrophoresis [28],LC-MS/MS [29], Atomic Absorbance [30] and molar refraction and polarizability method [31]. The main aim of the current work is to suggest an accurate and sensitive visible spectrophotometric method for the assay of METH as pure and in dosage form via oxidative -coupling reaction with 2,5-dihydroxybenzoic acid in presence of potassium periodate. ...
A simple, sensitive, and rapid spectrophotometric method has been developed for the determination of metoclopramide hydrochloride (METH). The method includes the oxidative coupling reaction of metoclopramide with 2,5-dihydroxybenzoic acid using potassium periodate as an oxidizing agent in an aqueous medium and at pH of 4.5 to give a water-soluble colored product. The highest absorbance occurs at a wavelength of 500 nm. The linear range of Beer's law was within the concentration range of 5-75 µg/ml of (METH) and the value of the molar absorptivity 2.196 x103 l.mol-1.cm-1 and Sandell's index value was equal to 0.0449 µg/ cm2. The relative standard deviation value was ≤ 2.98, while the LOD and LOQ values were 0.059 µg.ml-1 and 0.198 µg.ml-1 respectively. The proposed method was successfully applied in the spectrophotometric estimation of metoclopramide preparations in the form of tablets and injections with acceptable recovery.
... There are many different techniques that have been used for the determination of metoclopramide by various methods, including spectrophotometric methods [6,15], HPLC [16][17][18][19][20][21], potentiometric [22], Densitometric and UPLC methods [23], fluorometric [24], Flow Injection Chemiluminescence Technique [25], voltammetric [26], electrochemiluminescence [27],Capillary electrophoresis [28],LC-MS/MS [29], Atomic Absorbance [30] and molar refraction and polarizability method [31]. The main aim of the current work is to suggest an accurate and sensitive visible spectrophotometric method for the assay of METH as pure and in dosage form via oxidative -coupling reaction with 2,5-dihydroxybenzoic acid in presence of potassium periodate. ...
Keywords 2,5-dihydroxybenzoic acid ,metoclopramide hydrochloride; oxidati coupling ; potassium periodate, pectrophotometric. A simple, sensitive, and rapid spectrophotometric method has been developed for the determination of metoclopramide hydrochloride (METH). The method includes the oxidative coupling reaction of metoclopramide with 2,5-dihydroxybenzoic acid using potassium periodate as an oxidizing agent in an aqueous medium and at pH of 4.5 to give a water-soluble colored product. The highest absorbance occurs at a wavelength of 500 nm. The linear range of Beer's law was within the concentration range of 5-75 µg/ml of (METH) and the value of the molar absorptivity 2.196 x10 3 l.mol-1 .cm-1 and Sandell's index value was equal to 0.0449 µg/ cm 2. The relative standard deviation value was ≤ 2.98, while the LOD and LOQ values were 0.059 µg.ml-1 and 0.198 µg.ml-1 respectively. The proposed method was successfully applied in the spectrophotometric estimation of metoclopramide preparations in the form of tablets and injections with acceptable recovery. R M A Yassin and N S Othman Bas J Sci 40(2) (2022)465-485
A less environmentally harmful reagent, 2-tert-Butyl-4-methoxyphenol (BHA), is used to evaluate Metoclopramide hydrochloride (MCP.H) by simple, rapid, sensitive, accurate and precise spectrophotometric method, through azo coupling reaction between metoclopramide hydrochloride medicine and it's pharmaceutical preparation by utilizing BHA as a reagent, (MCP.H) azo-dye formed shows the higher absorption peak at 504 nm. Absorbance- concentration relation is linear over the range from 20 to 280 µg / 5 mL, (i.e. 4-56 ppm) with a good sensitivity (molar absorptivity 0.26x104 L.mol-1. cm-1); good precision (RSD better than 0.844 %) and high accuracy (relative error less than + 0.4%), Sandell's sensitivity index is -0.1293 µg.cm-2, the calculated limit of detection (LOD) is 0.0658 µg/mL and the evaluated limit of quantitation (LOQ) is 0.2193 µg/mL. The application has had successful results for the assay of metoclopramide hydrochloride in dosage forms of tablets and injection.
