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The relationship between laboratory findings and histopathological type and advanced-stage (TNM) in lung cancer group.
Source publication
We seek to define inflammatory markers, lipid and protein profiles that may aid in distinguishing lung cancer cases from those who are healthy and to determine the relationships between these levels and cancer stage and cell type. Lung cancer patients (n = 140, Group 1) and healthy cases (n = 50, Group 2) were enrolled. We retrieved platelet, plate...
Contexts in source publication
Context 1
... PDW did not differ significantly between the groups (p > 0.05, Table 1). No significant relationship was evident between histopathological subgroup and any marker (p > 0.05, Tables 2 and 3). According to the TNM stage, the associations of all markers (apart from the PDW) with advanced-stage cancer (stage 3 + stage 4, n = 101) were significantly greater than the associations with early-stage cancer (stage 1 + stage 2, n = 49) (p < 0.05, Table 2). ...
Context 2
... significant relationship was evident between histopathological subgroup and any marker (p > 0.05, Tables 2 and 3). According to the TNM stage, the associations of all markers (apart from the PDW) with advanced-stage cancer (stage 3 + stage 4, n = 101) were significantly greater than the associations with early-stage cancer (stage 1 + stage 2, n = 49) (p < 0.05, Table 2). In terms of metastasis status, the NLR was significantly higher in metastatic patients (p < 0.05, Table 3). ...
Context 3
... PDW did not differ significantly between the groups (p > 0.05, Table 1). No significant relationship was evident between histopathological subgroup and any marker (p > 0.05, Tables 2 and 3). According to the TNM stage, the associations of all markers (apart from the PDW) with advanced-stage cancer (stage 3 + stage 4, n = 101) were significantly greater than the associations with early-stage cancer (stage 1 + stage 2, n = 49) (p < 0.05, Table 2). ...
Context 4
... significant relationship was evident between histopathological subgroup and any marker (p > 0.05, Tables 2 and 3). According to the TNM stage, the associations of all markers (apart from the PDW) with advanced-stage cancer (stage 3 + stage 4, n = 101) were significantly greater than the associations with early-stage cancer (stage 1 + stage 2, n = 49) (p < 0.05, Table 2). In terms of metastasis status, the NLR was significantly higher in metastatic patients (p < 0.05, Table 3). ...
Context 5
... TP, TC, and LDL levels did not differ significantly between the groups (p > 0.05, Table 1). In those with advanced-stage (compared with early-stage) cancer, the albumin and HDL levels were significantly lower and the CRP level higher (p < 0.05, Tables 2 and 3). These levels were not affected by the histopathological cancer type (p > 0.05, Tables 2 and 3). ...
Context 6
... those with advanced-stage (compared with early-stage) cancer, the albumin and HDL levels were significantly lower and the CRP level higher (p < 0.05, Tables 2 and 3). These levels were not affected by the histopathological cancer type (p > 0.05, Tables 2 and 3). The NLR and CRP levels were significantly higher. ...
Citations
... The current mainstream biochemical sample testing on the market requires labeling of the samples being tested [6][7][8][9]. This labeling method is complex and time-consuming and can damage the tested samples. ...
To detect and differentiate two essential amino acids (L-Valine and L-Phenylalanine) in the human body, a novel asymmetrically folded dual-aperture metal ring terahertz metasurface sensor was designed. A solvent mixture of water and glycerol with a volume ratio of 2:8 was proposed to reduce the absorption of terahertz waves by reducing the water content. A sample chamber with a controlled liquid thickness of 15 μm was fabricated. And a terahertz time-domain spectroscopy (THz-TDS) system, which is capable of horizontally positioning the samples, was assembled. The results of the sensing test revealed that as the concentration of valine solution varied from 0 to 20 mmol/L, the sensing resonance peak shifted from 1.39 THz to 1.58 THz with a concentration sensitivity of 9.98 GHz/mmol∗L−1. The resonance peak shift phenomenon in phenylalanine solution was less apparent. It is assumed that the coupling enhancement between the absorption peak position of solutes in the solution and the sensing peak position amplified the terahertz localized electric field resonance, which resulted in the increase in frequency shift. Therefore, it could be shown that the sensor has capabilities in performing the marker sensing detection of L-Valine.
... Some scholars believe that there is an increase in MPV among patients with earlystage lung cancer, whereas it decreases in patients with advanced lung cancer (Sabrkhany et al. 2017;Goksel et al. 2021). Nevertheless, several scholars have discovered that the MPV among individuals diagnosed with lung cancer is comparatively lower than that observed in individuals who are unaffected by the disease (Şahin and Aslan 2018). The study discrepancy may be attributed to variances in cancer type and patient numbers across different stages. ...
Background
Non-small cell lung cancer (NSCLC) is the most common type of lung cancer (LC), which is the leading cause of tumor mortality. In recent years, compared with tissue biopsy, which is the diagnostic gold standard for tumor diagnosis, Liquid biopsy (LB) is considered to be a more minimally invasive, sensitive, and safer alternative or auxiliary diagnostic method. However, the current value of LB in early diagnosis of LC is not ideal, so it is particularly important to study the changes in blood composition during the process of tumorigenesis and find more sensitive biomarkers.
Purpose
Platelets are a type of abundant blood cells that carry a large amount of RNA. In the LC regulatory network, activated platelets play an important role in the process of tumorigenesis, development, and metastasis. In order to identify predictive liquid biopsy biomarkers for the diagnosis of NSCLC, we summarized the development and function of platelets, the interaction between platelets and tumors, the value of TEP RNA in diagnosis, prognosis, and treatment of NSCLC, and the method for detecting TEP RNA of NSCLC in this article.
Conclusion
The application of platelets in the diagnosis and treatment of NSCLC remains at a nascent stage. In addition to the drawbacks of low platelet count and complex experimental processes, the diagnostic accuracy of TEP RNA-seq for cancer in different populations still needs to be improved and validated. At present, a large number of studies have confirmed significant differences in the expression of TEP RNA in platelets between NSCLC patients and healthy individuals. Continuous exploration of the diagnostic value of TEP RNA in NSCLC is of utmost importance. The integration of NSCLC platelet-related markers with other NSCLC markers can improve current tumor diagnosis and prognostic evaluation systems, providing broad prospects in tumor screening, disease monitoring, and prognosis assessment.
... The molecules of amino acid play a crucial role in the normal functioning of various physiological process of human body, making the detection of amino acid concentrations an essential prerequisite for clinical diagnosis, drug development, and gene therapy [1][2][3][4][5]. Conventional detection methods for mainstream biochemical samples involve marked the samples [6][7][8][9]. This labeling approach is complex, time-consuming, and can damage the tested samples. ...
An asymmetric folded double-open ring of metasurface sensor based on the Fano resonance has been designed, with its resonant frequency matching the absorption peak of L-Valine at 1.7 THz. A mixture of water and glycerol in a volume ratio of 2:8 was proposed as a solvent to reduce the absorption of terahertz waves by water. A sample chamber with a controlled liquid thickness of (15 μm) was fabricated. A vertical incidence of terahertz time-domain spectrometer (THz-TDS) was constructed to allow solutions to be placed horizontally, and two different concentrations of amino acid solutions were subsequently measured. As the concentration of L-Valine solution varied from 0 to 20mM, the resonance peak of sensor shifted from 1.39 THz to 1.58 THz, demonstrating a concentration sensitivity of 9.98GHz/mM. The resonance peak shift in the L-Phenylalanine solution was not pronounced. It is speculated that the coupling enhancement between the solute absorption peak and the sensor resonance peak in the solution leads to an increased frequency shift, highlighting the distinctive sensing detection.
... The surface proteins of VLDL include apolipoprotein (Apo) B-100, Apo C-I, Apo C-II, Apo C-III, and Apo E. Among these, Apo B-100 is the core structural protein and is produced by the liver [22]. A research revealed that VLDL levels were elevated in lung cancer patients compared to non-cancer subjects [23]. In addition, VLDL promote breast cancer progression and metastasis through Akt-induced (epithelial-mesenchymal transition) EMT and angiogenesis [24]. ...
Background
Current evidence suggests a significant association between metabolites and ovarian cancer (OC); however, the causal relationship between the two remains unclear. This study employs Mendelian randomization (MR) to investigate the causal effects between different metabolites and OC.
Methods
In this study, a total of 637 metabolites were selected as the exposure variables from the Genome-wide Association Study (GWAS) database (http://gwas.mrcieu.ac.uk/datasets/). The OC related GWAS dataset (ieu-b-4963) was chosen as the outcome variable. R software and the TwoSampleMR package were utilized for the analysis in this study. MR analysis employed the inverse variance-weighted method (IVW), MR-Egger and weighted median (WM) for regression fitting, taking into consideration potential biases caused by linkage disequilibrium and weak instrument variables. Metabolites that did not pass the tests for heterogeneity and horizontal pleiotropy were considered to have no significant causal effect on the outcome. Steiger’s upstream test was used to determine the causal direction between the exposure and outcome variables.
Results
The results from IVW analysis revealed that a total of 31 human metabolites showed a significant causal effect on OC (P < 0.05). Among them, 9 metabolites exhibited consistent and stable causal effects, which were confirmed by Steiger’s upstream test (P < 0.05). Among these 9 metabolites, Androsterone sulfate, Propionylcarnitine, 5alpha-androstan-3beta,17beta-diol disulfate, Total lipids in medium VLDL and Concentration of medium VLDL particles demonstrated a significant positive causal effect on OC, indicating that these metabolites promote the occurrence of OC. On the other hand, X-12,093, Octanoylcarnitine, N2,N2-dimethylguanosine, and Cis-4-decenoyl carnitine showed a significant negative causal association with OC, suggesting that these metabolites can inhibit the occurrence of OC.
Conclusions
The study revealed the complex effect of metabolites on OC through Mendelian randomization. As promising biomarkers, these metabolites are worthy of further clinical validation.
... MPV reflects platelet production in the bone marrow. A high MPV indicates high platelet production, and a low MPV indicates low platelet production [23,24]. A previous study revealed that newly diagnosed adult patients with primary ITP with high baseline MPV were more likely to respond to firstline treatment [12]. ...
Background
Treatment options for pregnant women with immune thrombocytopenia (ITP) who do not respond to first-line treatment are limited. Few studies have reported the use of recombinant human thrombopoietin (rhTPO) for this subset of patients.
Aims
To investigate the efficacy and safety of rhTPO in ITP during pregnancy and determine obstetric outcomes and predictors of treatment response.
Methods
From July 2013 to October 2022, the data of 81 pregnant women with ITP and a platelet count < 30 × 10⁹/L who did not respond to steroids and/or intravenous immunoglobulin were retrospectively analysed. Of these patients, 33 received rhTPO treatment (rhTPO group) while 48 did not (control group). Baseline characteristics, haematological disease outcomes before delivery, obstetric outcomes, and adverse events were compared between groups. In the rhTPO group, a generalised estimating equation (GEE) was used to investigate the factors influencing the response to rhTPO treatment.
Results
The baseline characteristics were comparable between both groups (P > 0.05, both). Compared with controls, rhTPO patients had higher platelet counts (median [interquartile range]: 42 [21.5–67.5] vs. 25 [19–29] × 10⁹/L, P = 0.002), lower bleeding rate (6.1% vs. 25%, P = 0.027), and lower platelet transfusion rate before delivery (57.6% vs. 97.9%, P < 0.001). Gestational weeks of delivery (37.6 [37–38.4] vs 37.1 [37–37.2] weeks, P = 0.001) were longer in the rhTPO group than in the control group. The rates of caesarean section, postpartum haemorrhage, foetal or neonatal complications, and complication types in both groups were similar (all P > 0.05). No liver or renal function impairment or thrombosis cases were observed in the rhTPO group. GEE analysis revealed that the baseline mean platelet volume (MPV) (odds ratio [OR]: 0.522, P = 0.002) and platelet-to-lymphocyte ratio (PLR) (OR: 1.214, P = 0.025) were predictors of response to rhTPO treatment.
Conclusion
rhTPO may be an effective and safe treatment option for pregnancies with ITP that do not respond to first-line treatment; it may have slightly prolonged the gestational age of delivery. Patients with a low baseline MPV and high baseline PLR may be more responsive to rhTPO treatment. The present study serves as a foundation for future research.
... Recently, coagulation-related parameters have been proven important in tumors' occurrence, development, and metastasis [7,8]. Previous studies have reported that hypercoagulability in patients with malignant tumors may promote tumor invasion and metastasis [9,10]. ...
... Previous studies have reported that hypercoagulability in patients with malignant tumors may promote tumor invasion and metastasis [9,10]. In addition, unique diagnostic applications and prognostic significance of coagulation markers have been observed in various malignancies, including colorectal, lung, breast, and gastric cancer [8]. Nevertheless, the application of coagulation-related markers in laryngeal cancer remains unclear. ...
... Exclusion criteria were defined as (1) preoperative adjuvant therapy, including radiotherapy, chemotherapy, immunotherapy, and endocrine therapy (2) postoperative pathological diagnosis of non-LSCC (3) combined with infection, liver and kidney disease, blood system disease, and other acute and chronic diseases affecting coagulation and platelet index (4) oral drugs affecting coagulation and platelet index (5) preoperative distant metastasis (6) combined with other non-LSCC tumor history (7) incomplete clinical data (8) giving up treatment. Laryngeal disease patients with a pathologically benign diagnosis were included as the control group. ...
Background:
The application of coagulation-related markers in laryngeal squamous cell carcinoma(LSCC) remains unclear. This study explored the prognostic role of coagulation markers in the progression and metastasis of LSCC.
Methods:
Coagulation markers of patients with LSCC receiving surgery in the Second Affiliated Hospital of Fujian Medical University in China, from January 2013 to May 2022 were retrospectively analyzed and compared with those of contemporary patients with benign laryngeal diseases. The relationship between clinicopathological features of LSCC and coagulation markers was analyzed with the chi-square and rank sum tests. The ROC curve analysis was utilized to evaluate the diagnostic efficacy of seven coagulation markers for LSCC and its different clinicopathological features, and to find the optimal cutoff value of each coagulation marker.
Results:
303 patients with LSCC and 533 patients with benign laryngeal diseases were included in the present analysis. Compared to the control group, prothrombin time (PT) (p < 0.001), activated partial thromboplastin time (APTT) (p = 0.001), and Fib (p < 0.001) in patients with LSCC were significantly higher, while mean platelet volume (MPV) (p < 0.001) was significantly shorter. Significant increases were detected in PT (Z = 14.342, p = 0.002), Fib (Z = 25.985, p < 0.001), platelet count (PC) (Z = 12.768, p = 0.005), PCT (Z = 9.178, p = 0.027), MPV (F = 2.948, p = 0.033) in T4 stage. Fib had the highest prognostic value among the seven coagulation markers in different T stages (AUC = 0.676, p < 0.001), N stages (AUC = 0.717, p < 0.001), tumor stage (AUC = 0.665, p < 0.001), differentiation degree (AUC = 0.579, p = 0.022), and neurovascular invasion (AUC = 0.651, p = 0.007). Fib (Z = 25.832, p < 0.001), PC (Z = 23.842, p < 0.001), and PCT (Z = 20.15, p < 0.001) in N1 and N3 stages were significantly higher than in N0 stage. PT (Z = 12.174, p = 0.007), Fib (Z = 23.873, p < 0.001), PC (Z = 17.785, p < 0.001), and PCT (Z = 14.693, p = 0.002) were significantly higher in stage IV than in stage I and II. APTT (Z=-1.983, p = 0.047), Fib (Z=-2.68, p = 0.007), PC (Z=-2.723, p = 0.006), and PCT (Z=-2.592, p = 0.01) increased significantly when the tumor invaded neurovascular tissue.
Conclusions:
Coagulation markers have the potential to act as biomarkers for predicting pathological features of LSCC. The high level of Fib was helpful for the diagnosis of LSCC and the detection of advanced LSCC.
Trial registration:
Not applicable.
... 26 In recent years, a large number of studies have shown that inflammation is closely related to the occurrence and development of tumors, which can be reflected by blood test. [27][28][29] The mechanism may be related to the following factors. Inflammatory cells secrete a variety of cytokines, chemokines, and adhesion molecules that promote cell proliferation and angiogenesis. ...
Background:
There are few clinical symptoms in early colorectal cancer, so it is necessary to find a simple and economical tumor detection index for auxiliary diagnosis. This study aims to explore the diagnostic value of preoperative inflammation-related indicators, such as neutrophil, lymphocyte, platelet count, platelet to lymphocyte ratio (PLA), neutrophil to lymphocyte ratio (NLR), and systemic immune-inflammation index (SII), for early colorectal cancer, and determine whether inflammation-related indicators can provide more accurate diagnostic judgment for patients.
Methods:
This study was a retrospective study. Patients who were first diagnosed with colorectal cancer or colorectal adenomatous polyp at Beijing Friendship Hospital from October 2016 to October 2017 were retrospectively collected. According to inclusion and exclusion criteria, a total of 342 patients were included, including 216 patients with colorectal cancer and 126 patients with colorectal adenomatous polyp. Fasting venous blood and other clinical features were collected to compare the differences between colorectal cancer and colorectal adenoma.
Results:
There were statistically significant differences in age, carcinoembryonic antigen, albumin, hemoglobin, mean platelet volume, lymphocyte, monocyte, NLR, PLA, SII, and mean platelet volume to platelet count ratio between colorectal cancer group and colorectal adenoma group (P < .05), and a Nomogram model was established. Using inflammatory markers to differentiate colorectal and colorectal polyps produced greater AUC than using tumor markers alone (.846 vs .695).
Conclusion:
Inflammation-related indicators, such as lymphocyte, monocyte, and mean platelet volume, may serve as potential indicators to assist in the diagnosis of early colorectal cancer.
... The lipid and lipoprotein transport system plays a crucial role in the pathogenesis and progression of many types of cancer [50], such as colorectal cancer [51][52][53], lung cancer [54,55], breast cancer [56], ovarian cancer [57], thyroid cancer [58], gastric cancer [59], and multiple myeloma (MM) [60]. ...
High-density lipoprotein (HDL) is an enigmatic member of the plasma lipid and lipoprotein transport system, best known for its ability to promote the reverse cholesterol efflux and the unloading of excess cholesterol from peripheral tissues. More recently, data in experimental mice and humans suggest that HDL may play important novel roles in other physiological processes associated with various metabolic disorders. Important parameters in the HDL functions are its apolipoprotein and lipid content, further reinforcing the principle that HDL structure defines its functionality. Thus, based on current evidence, low levels of HDL-cholesterol (HDL-C) or dysfunctional HDL particles contribute to the development of metabolic diseases such as morbid obesity, type 2 diabetes mellitus, and nonalcoholic fatty liver disease. Interestingly, low levels of HDL-C and dysfunctional HDL particles are observed in patients with multiple myeloma and other types of cancer. Therefore, adjusting HDL-C levels within the optimal range and improving HDL particle functionality is expected to benefit such pathological conditions. The failure of previous clinical trials testing various HDL-C-raising pharmaceuticals does not preclude a significant role for HDL in the treatment of atherosclerosis and related metabolic disorders. Those trials were designed on the principle of “the more the better”, ignoring the U-shape relationship between HDL-C levels and morbidity and mortality. Thus, many of these pharmaceuticals should be retested in appropriately designed clinical trials. Novel gene-editing-based pharmaceuticals aiming at altering the apolipoprotein composition of HDL are expected to revolutionize the treatment strategies, improving the functionality of dysfunctional HDL.
... The onset and development of cancer are significantly influenced by systemic inflammation. Hematological parameters including serum lymphocyte, monocyte, neutrophil, and platelet counts, and NLR, LMR, and PLR calculated using these cell counts are prognostic parameters for malignancies (2,20,21). Recent studies have shown that certain blood markers, such as the ratio of neutrophils to lymphocytes (NLR), the ratio of platelets to lymphocytes (PLR), and the ratio of lymphocytes to monocytes (LMR), represent inflammatory changes in the tumor microenvironment (22). ...
Aim: Malignant pleural mesothelioma (MPM) is an extremely mortal condition. Only a few prognostic biomarkers have been described for MPM. Our study looked into the association between patient survival and the Systemic Immune Inflammation Index (SII). Material and Method: A total of 158 patients who were admitted to our hospital between January 2013 and December 2022, and had a histopathologically confirmed diagnosis of MPM were included in the study. Before treatment, hematological parameters and SII were determined. A Spearman's correlation analysis was performed to analyze the correlation of mean survival with hematological parameters. Results: The study involved 158 patients in all. 70 patients had a history of smoking, the median age was 63 years, the mean survival time was 15.3 months, and 57.6% of the participants were men. The epithelioid type (84.2%) was the most prevalent histological subtype, and 29 patients had stage 4 illnesses. Of the participants, 84% had received chemotherapy, and 22% had received radiotherapy before. Among the 39 patients who had surgery, 5 had an extrapleural pneumonectomy. SII mean±sd was (1427.2±1207.3). The patients with stage 4 disease had significantly shorter survival (p=0.001). The patients who had surgery survived significantly longer (p=0.01). Hemoglobin (Hb) (r:0.21, p:0.01) and Hematocrit (Hct) (r:0.18, p:0.03) values showed weak positive correlations with mean survival. It was evident that mean survival got shorter as SII (r:-0.17, p:0.04) and neutrophil-lymphocyte ratio (NLR) (r:-0.19, p:0.02) values got higher. On the other hand, there was a strong positive association between mean survival and the lymphocyte-monocyte ratio (LMR) (r:0.21, p:0.01). When the parameters that had statistically significant differences among the groups were taken as control variables and the statistical analysis was re-performed, it was found that Hgb and Hct values as well as NLR and LMR ratios lost their significant correlations with survival. However, the SII ratio was still negatively correlated with survival (r:-0.16, p:0.04). Conclusion: Pretreatment SII is a noninvasive and easy-to-calculate biomarker that predicts the prognosis of MPM. It is negatively correlated with mean survival regardless of the tumor stage and surgical management.
... The most common abnormalities, linked to chronic inflammatory processes accompanying neoplasia, are represented by leukocytosis, neutrophilia, thrombocytopenia, and lymphocytopenia. These may occur during the growth and lysis of the tumor [17,25,26]. The positive feedback of immunoregulatory cytokines in the recruitment of tumor-associated neutrophils induces disease progression and increases the risk of distant metastasis; platelets also appear to have a similar role. ...
Simple Summary
Systemic inflammation and changes in the inflammatory status are frequent features of lung cancer. There is a close interconnection between cancer development and the clinical, general, and inflammatory status of patients. In this paper, we evaluate a large panel of inflammatory indexes in patients who underwent lung resection for NSCLC lung cancer; we show that pre-operative inflammatory status strongly influences long-term prognosis in patients affected by NSCLC and undergoing surgery.
Abstract
Background (1): Our goal was to investigate if and how pre-operative inflammatory status can influence the long-term prognosis of patients undergoing lung surgery for cancer. Materials and Methods (2): This prospective observational study includes the agreement of all operable patients to the study, who were referred to our department between 1 January 2017 and 30 December 2018. The inflammatory pre-operative status of the patients was investigated by calculating albumin, CPR (c-protein reactive), complete blood count (neutrophils, lymphocytes, platelets, hemoglobin), and some other indexes referring to inflammatory status, namely the HALP amalgamated index, platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocytes ratio (NLR), systemic immune-inflammation index (SII), and advanced lung cancer inflammation Index (ALI). The follow-up ended in November 2021. Patient overall survival was assessed using the Kaplan–Meier method. The log-rank test was used to compare survival rates. Variables significantly associated with survival at univariate analysis were entered int Cox multivariate analysis (stepwise mode) to assess their independent character. Hazard ratios and their 95% confidence intervals were calculated. Variables associated with p < 0.05 were considered significative. Results (3): We enrolled 257 patients in our study. The overall survival of the cohort was as follows: 1 year, 96.1%; 3 year, 81.3%; and 4 year, 74.2%. Univariate analysis showed risk factors for overall survival as follows: Thoracoscore ≥ 2 (p = 0.002); histology (p = 0.002); HALP < 32.2 (p = 0.0002); SII ≥ 808.9 (p = 0.0004); ALI < 34.86 (p = 0.0005); NLr ≥ 2.29 (p = 0.01); hemoglobin < 13 g/dl (p = 0.01); PLR ≥ 196.1 (p = 0.005); pN+ (p < 0.0001); pleural invasion (p = 0.0002); and presence of vascular or lymphatic tumor emboli (p = 0.0002). Multivariate Cox analysis (stepwise model) identified Thoracoscore ≥ 2 (p = 0.02); histology, HALP < 32.2 (p = 0.004), and pN (p < 0.0001) as independent predictors of death. Conclusion (4): Pre-operative inflammatory status strongly influences long-term prognosis in patients affected by NSCLC and undergoing surgery.
