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The plasma cells were morphologically mature at diagnosis and for the first few years of treatment, with eccentric nuclei, clumped chromatin, and low nuclearcytoplasmic ratios (a, b). Rare forms with prominent nucleoli are seen. (a Aspirate smear, Wright-Giemsa, ×500. b. Core biopsy, hematoxylin and eosin, ×500)

The plasma cells were morphologically mature at diagnosis and for the first few years of treatment, with eccentric nuclei, clumped chromatin, and low nuclearcytoplasmic ratios (a, b). Rare forms with prominent nucleoli are seen. (a Aspirate smear, Wright-Giemsa, ×500. b. Core biopsy, hematoxylin and eosin, ×500)

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Plasma cell myeloma (PCM) is a hematological malignancy involving clonal proliferation of plasma cells in bone marrow. It is the third most common hematolymphoid malignancy in the USA and primarily affects elderly people with a median onset age of 69 years and a survival duration ranging from a few months to more than 10 years. This variation is du...