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The pathophysiology of acute pancreatitis

The pathophysiology of acute pancreatitis

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Endoscopic retrograde cholangiopancreatography (ERCP) is the most commonly used treatment for patients with disorders of the bile ducts and pancreas. More than 6,000 procedures are annually performed in Denmark. The procedure is associated with a 5-15% risk of subsequent acute inflammation of the pancreas entitled post-ERCP pancreatitis (PEP). Panc...

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Context 1
... Another common etiology is endoscopic retrograde cholangiopancreatography (ERCP) in the form of post-ERCP pancreatitis (PEP). Other etiologies include: Idiopathic, hyperlipidemia, hyperparathyroidism, pharmaceuticals, pancreatic cancer etc. 5 Regardless of etiology, the initial activation of trypsinogen to trypsin in the acinar cells and subsequent activation of other proenzymes is considered the primary initiator of the pathogenesis of AP (Figure 1). ...