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![The number of gene alleles and peptides of each MHC locus of human MHC I and II, as reported by the WHO Nomenclature Committee for Factors of the HLA System [30].](publication/357748453/figure/tbl1/AS:1111119104098304@1641922846369/The-number-of-gene-alleles-and-peptides-of-each-MHC-locus-of-human-MHC-I-and-II-as.png)
The number of gene alleles and peptides of each MHC locus of human MHC I and II, as reported by the WHO Nomenclature Committee for Factors of the HLA System [30].
Source publication
Major Histocompatibility Complex (MHC) molecules play a crucial role in inducing an adaptive immune response. T-cell epitopes require compatible MHC molecules to form MHC-peptide Complexes (pMHC) that activate the T-cell Receptors (TCR) of T-lymphocyte clones. MHCs are polymorphic molecules with wide varieties of gene alleles. There are two classes...
Context in source publication
Context 1
... combination of the alpha and beta peptides of HLA-II results in the possible variants of HLA-II molecules more than HLA-I molecules. The numbers of alleles and proteins of MHC class I and II, as reported by the WHO Nomenclature Committee for Factors of the HLA System, are shown in Table 1 [30]. ...Similar publications
The human leukocyte antigen (HLA) system comprises the most polymorphic genes of the human genome and is famous for its potential pathological roles. To accurately type HLA genes and find HLA-matched donors, which are critical for effective hematopoietic transplantation, HLA typing using next-generation sequencing (NGS) was implemented. We aimed to...
Citations
After exposure to SARS-CoV-2, varying symptoms of COVID-19 ranging from asymptomatic symptoms to morbidity and mortality have been exhibited in each individual. SARS-CoV-2 requires various cellular molecules for penetration into a target host cell. Angiotensin-converting enzyme2 (ACE2) acts as the viral receptor molecule. After attachment, SARS-CoV-2 also requires the transmembrane protease serine-2 (TMPRSS-2) and furin molecules, which serve as co-receptors for penetration into the target cell and for subsequent replication. In the meantime, a major histocompatibility complex (MHC) is required for the induction of adaptive immune cells, especially cytotoxic T cells and helper T cells, to clear the virally infected cells. This perspective review article proposes different aspects to explain the varying symptoms of the individuals who have been exposed to SARS-CoV-2, which relates to the polymorphisms of these involved molecules.
