Figure 1 - uploaded by Santiago R. Unda
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The linear processing pathway of miRNA. The formation of the RNA-induced gene silencing complex (RISC) is capable of executing RNA interference (RNAi)-related gene silencing, concluding in mRNA deadenylation, translational repression and mRNA cleavage.
Source publication
MiRNAs are single-stranded small noncoding RNAs that consist of approximately 22 nucleotides, that are involve in a wide range of biological processes including pain physiopathology. Because of their role as master switches in regulation and signaling pathways through modifications in nociceptive receptors, ion channels, pro-inflammatory molecules,...
Citations
... MiRNAs are single-stranded small noncoding RNAs that consist of approximately 22 nucleotides [13]. This molecules have been involved in a wide range of biological process including vascular diseases. ...
Intracranial aneurysms (IAs) are sac-like dilatations of arteries inside the brain. This pathology can cause severe neuronal and non-neuronal injuries with high impact in the quality of life. Recently, MicroRNAs have been proposed to be a major switch in a wide variety of vascular diseases including the ones in which vascular smooth muscle cells (VSMCs) changes it`s phenotype. The critical role that miR`s may have in the development, progression, and rupture of aneurysms propose them to be a potential tool as a predictor biomarker for clinical diagnostic and progression and also as a future target for new therapeutic interventions. However, miRNAs and their connection with target genes require much efforts before miRNA expression analysis is applied in the clinical practice.
