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The initial Table 1. Tetracycline production by the different strains when cultivated on peanut shells at 68% moisture content at 3 I °C for 5 days.
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The ability of Streptomyces sp. OXCI, S. rimosus NRRL B2659, S. rimosus NRRL B2234, S. alboflavus NRRL B1273 S. aureofaciens NRRL B2183 and S. vendagensis ATCC 25507 to produce tetracycline using some local agricultural wastes as solid state media, were assessed. The wastes employed include peanut (groundnut) shells, corncob, corn pomace and cassav...
Citations
... Utilizing groundnut shells as the raw material and a strain of Streptomyces rimosus, Oxytetracycline was synthesized using SSF. [60] . This method of production of oxytetracycline was also supported by [61] and [62]. ...
Biotechnology is one of the emerging fields that can add new and better application in a wide range of sectors like health care, service sector, agriculture, and processing industry to name some. This book will provide an excellent opportunity to focus on recent developments in the frontier areas of Biotechnology and establish new collaborations in these areas. The book will highlight multidisciplinary perspectives to interested biotechnologists, microbiologists, pharmaceutical experts, bioprocess engineers, agronomists, medical professionals, sustainability researchers and academicians. This technical publication will provide a platform for potential knowledge exhibition on recent trends, theories and practices in the field of Biotechnology
... Agro-waste also contains many bioactive compounds such as polyphenols, tannins, flavonoids, vitamins, essential minerals, fatty acids, volatiles, anthocyanins, pigments, bioactive peptides, whey, and colostrum (Ben-Othman et al. 2020). Asagbra et al. (2005) investigated the presence of antibiotics in agro-waste in which peanut shells were identified as the most productive substrate for tetracycline (4.36 mg g -1 ), followed by corncobs (Asagbra et al. 2005). Therefore, agro-waste is a plausible source for pharmaceuticals and other nutrients and minerals, rendering it a feasible option that will aid in fulfilling the increasing demand for nutrients in the health sector. ...
... Agro-waste also contains many bioactive compounds such as polyphenols, tannins, flavonoids, vitamins, essential minerals, fatty acids, volatiles, anthocyanins, pigments, bioactive peptides, whey, and colostrum (Ben-Othman et al. 2020). Asagbra et al. (2005) investigated the presence of antibiotics in agro-waste in which peanut shells were identified as the most productive substrate for tetracycline (4.36 mg g -1 ), followed by corncobs (Asagbra et al. 2005). Therefore, agro-waste is a plausible source for pharmaceuticals and other nutrients and minerals, rendering it a feasible option that will aid in fulfilling the increasing demand for nutrients in the health sector. ...
Agricultural industries are the largest waste producer that comprises a major problem worldwide due to the adverse effect of agro-waste on the environment, economy, and social life. Annually 1300 million tons of trash are produced from the agricultural fields, out of which up to 50% are raw materials dumped without treatment. Therefore, minimising agricultural solid waste is imperative to combat its detrimental effects on the health of humans and other animals. Furthermore, agro-waste contains different bioactive compounds such as lignin, cellulose, chitin, and polyphenolic compounds; therefore, it can be envisaged as a potential source for producing biofertiliser, biofuel, biogas, enzymes, vitamins, antioxidants, and other value-added products. Additionally, utilising agro-waste as a raw material diminishes production costs and provides the scope of additional revenue for the reliant industries. Also, the synchronised recovery of renewable energy and wastewater treatment through bioelectrochemical systems (BES) utilising agro-waste products as feedstock demonstrates a waste biorefinery approach leading towards a sustainable circular bioeconomy. Therefore, this chapter elucidates the application of different agro-waste products in the field of BES and their effects on bioenergy production and other value-added product recoveries. Moreover, this chapter aims to enlighten the readers on the advancements in biochemical processes for agro-waste remediation and biochemical conversion technologies to recover valuable biochemicals. In addition, different roadblocks associated with biochemical conversion technologies, considering recommendations and future perspectives, are also highlighted. Additionally, recent developments in potential imminent research areas of agro-waste-assisted BES have also been covered to make this nascent technology ready for large-scale implementation.
... strain FRX14, [30] which possess prodigiosin and ectoine gene clusters, respectively. Additionally, Streptomyces alboflavus (NRRL B-1273), a known tetracycline producer, [33] was included. Prodigiosin is a basic and highly aromatized compound [31] tetracycline is a moderately polar polyketide synthase product, [32] and ectoine is small zwitterionic and highly polar compound for which we have been unable to achieve acceptable retention with C18 columns (Fig. 20). ...
Atmospheric Solids Analysis Probe (ASAP) mass spectrometry is a versatile technique allowing direct sampling of solid and liquid samples, but its adoption is limited due to the high cost of commercial ASAP systems. To address this, we present OpenASAP, an open-source ASAP system for mass spectrometers that can be fabricated for $20 or less using 3D-printing. Our design is readily adaptable to instruments from different manufacturers and can be produced with a variety of additive manufacturing techniques on consumer-grade 3D-printers. The probe allows for rapid sampling of solid and liquid samples without sample preparation, making it useful for high throughput screening, investigating spatial localization and function of analytes in biological samples, and incorporating mass spectrometry in instructional settings. We demonstrate its effectiveness by obtaining mass spectra of three natural product standards at levels as low as 10 ng/ml in liquid samples, and detecting these metabolites in microbial cultures that are difficult to analyze due to complex sample matrices or analyte properties. Furthermore, we demonstrate direct sampling of thin layer chromatography (TLC) spots of these cultures.
... mg/g dried substrate ) [399]; tetracycline by different Streptomyces strains from agricultural wastes including groundnut shells, corncob, corn pomace and cassava peels, with the Streptomyces sp. OXCq gives the highest tetracycline production (13.18 mg/g) on peanut shells as substrate in solid fermentation [400], and oxytetracycline by Streptomyces spp. on groundnut shells, corncob, corn pomace, and cassava peels, with Streptomyces vendagensis ATCC 25507 producing 120 mg/g of oxytetracycline on groundnut shells [401]. ...
The sustainable management of lignocellulosic agricultural waste has gained significant attention due to its potential for the production of valuable products. This paper provides an extensive overview of the valorization strategies employed to convert lignocellulosic agricultural waste into economically and environmentally valuable products. The manuscript examines the conversion routes employed for the production of valuable products from lignocellulosic agricultural waste. These include the production of biofuels, such as bioethanol and biodiesel, via biochemical and thermochemical processes. Additionally, the synthesis of platform chemicals, such as furfural, levulinic acid, and xylose, is explored, which serve as building blocks for the manufacturing of polymers, resins, and other high-value chemicals. Moreover, this overview highlights the potential of lignocellulosic agricultural waste in generating bio-based materials, including bio-based composites, bio-based plastics, and bio-based adsorbents. The utilization of lignocellulosic waste as feedstock for the production of enzymes, organic acids, and bioactive compounds is also discussed. The challenges and opportunities associated with lignocellulosic agricultural waste valorization are addressed, encompassing technological, economic, and environmental aspects. Overall, this paper provides a comprehensive overview of the valorization potential of lignocellulosic agricultural waste, highlighting its significance in transitioning towards a sustainable and circular bioeconomy. The insights presented here aim to inspire further research and development in the field of lignocellulosic waste valorization, fostering innovative approaches and promoting the utilization of this abundant resource for the production of valuable products.
... Tanto las formulaciones de los medios de cultivo usados para el inóculo, como la del medio de fermentación, al igual que las condiciones de proceso, fueron descritas al detalle, aunque no existió un proceso de extracción del antibiótico. Un ensayo semejante fue realizado por Asagbra et al [15] usando medios de cultivo sólido a base de cáscaras de cacahuate, mazorcas de maíz, cáscaras de yuca y cáscaras con pulpa de manzana, adicionadas de sales minerales y fuente de nitrógeno, inoculadas por separado con varias especies de Streptomyces. Los resultados mostraron que hubo producción significativa de tetraciclina y aunque la formulación del medio fue descrita al detalle al igual que las condiciones de proceso, la producción fue a nivel laboratorio y el proceso de recuperación industrial no fue manejado. ...
... Several research projects employing agro-industrial waste to manufacture antibiotics were conducted. Asagbra et al. [73] investigated antibiotics out of a variety of agricultural byproducts and waste products. When it came to the generation of tetracycline, peanut shells proved to be the most productive substrate at 4.36 mg/g, followed by corncobs. ...
The agricultural sector generates a significant amount of waste, the majority of which is not productively used and is becoming a danger to both world health and the environment. Because of the promising relevance of agro-residues in the agri-food-pharma sectors, various bioproducts and novel biologically active molecules are produced through valorization techniques. Valorization of agro-wastes involves physical, chemical, and biological, including green, pretreatment methods. Bioactives and bioproducts development from agro-wastes has been widely researched in recent years. Nanocapsules are now used to increase the efficacy of bioactive molecules in food applications. This review addresses various agri-waste valorization methods, value-added bioproducts, the recovery of bioactive compounds, and their uses. Moreover, it also covers the present status of bio-active micro-and nanoencapsulation strategies and their applications.
... At working moisture content of 65-70%, pH 5 and fermentation for 6 days, Streptomyces vendagensis ATCC 25,507 among the strains that were studied produced 120 mg/g oxytetracycline when grown on groundnut shells in SSF. In a related study, strains of Streptomyces were studied for the production of tetracycline on agricultural wastes by Asagbra et al. (2005b) . The study reported that among all the tested organisms, Streptomyces sp. ...
Waste biorefinery concept is gaining attention in converting wastes to industrial products. This is of paramount importance within sustainability paradigm of utilization of resources and contribution to emerging circular bioeconomy and responsible consumption. Among the vast resources that can be up-graded through value-addition are agrowastes that are generated through processing of crops. Agrowastes contain rich compounds, but the presence of complex molecules such as cellulose, hemicellulose and lignin and anti-nutritional compounds that include cyanogenic glycosides, oxalates, phytates and trypsin inhibitors limits their utilization. Thus, they are often disposed in large quantities in the environment in manners that contribute to pollution. However, with increased awareness about detrimental effects of burning and burying of agrowastes, coupled with developments in circular bioeconomy that focus on ‘no waste’ generation mantra, various technologies have been developed to valorize these wastes into useful products. Among such wastes are melon seed shell, groundnut shell and groundnut peel. This review documents valorization of aforementioned agrowastes through various biotechnological routes to create different products. Until now, there is no review on their valorization unlike vast reviews on the utilization of melon and groundnut cakes. The report addresses issues that can ensure better utilization of these wastes for the attainment of some sustainable development goals (SDGs) of the United Nations, particularly good health and well-being (SDG 3), clean water and sanitation (SDG 6), industry, innovation and infrastructure (SDG 9), responsible consumption and production (SDG 12) and action against climate change (SDG 13).
... Loloatin B Antibacterial [92] Bacillus amyloliquefaciens Macrolactin S Antibacterial [93] Bacillus amyloliquefaciens Macrolactin V Antibacterial [93] Bacillus laterosporus Basiliskamides Antifungal [94] Streptomyces misionensis Streptenols Antibacterial [95] Streptomyces spp. Dibohemamines Antimicrobial [96] Thermoactinomyces vulgaris Thermoactinoamide A Antimicrobial [97] Streptomyces clavuligerus Cephalosporins Antibacterial [98] Streptomyces cattleya Thienamycin Antibacterial [99] Streptomyces erythraea Erythromycin Antibacterial [100] Streptomyces orientalis Vancomycin Antibacterial [101] Streptomyces griseus Streptomycin Antibacterial [102] Marantochloa purpurea Gentamycin Antibacterial [103] Streptomyces spp., Tetracyclines Antibacterial [104] Pseudomonas fluorescens Mupirocin Antibacterial [105] Streptomyces roseosporus Daptomycin Antibacterial [106] Streptomyces nodosus AmphotericinB Antifungal [107] Nocardiopsis alba Z)-1-((1-hydroxypenta-2,4-dien1-yl) oxy) anthracene-9,10-dione Antibacterial [108] Streptomyces spp. HW-003 AMRSA1 Antibacterial [109] Streptomyces spp.C34 Chaxamycins Antibacterial [110] Streptomyces kanamyceticus Bekanamycin Antibacterial [111] Streptomyces triticiradicis sp. ...
... Diverse agriculture wastes are utilized for the manufacturing of different antibiotics. Oxytetracycline were produced in solid state fermentation using corn cobs, sawdust, and rice hulls as solid support and in another study groundnut shell was used as solid substrate and effectively using Streptomyces rimosus culture (Ifudu Ifudu 1986;Asagbra et al. 2005). Contribution of exterior energy resource was utilized for improved manufacturing of antibiotic. ...
The food industry is generating huge amounts of by-products, about 1,890,000 tons, which should be better recycled into pharmaceuticals, cosmetics and functional foods, for instance, in order to save costs and avoid pollution. Here we review food by-products and methods of extraction. We present bioactive compounds from fruits, vegetable, tea, coffee, egg, nuts, meat and dairy products. Extracting methods include soxhlet, maceration, microwave, ultrasound, pressure.
... Ifudu [127] found that corn cobs, sawdust, and hulls of rice were able to produce antibiotics like oxytetracycline. Asagbra et al. [128] from the waste of groundnut shells through a solid waste fermentation process using Streptomyces rimosus as the microbial aid produced massive antibiotics. The findings of Yang and Swei [129] and Ingale et al. [130] validated the synthesis of antibiotics via the use of agricultural waste materials [131]. ...
Numerous quantities of plant-derived wastes are a common sight in agro-industrial processes, agricultural retail markets, processing plants and several phases of the agricultural value chain. Much of these wastes are underutilized and have been recognized as one of the major factors responsible for serious environmental pollution if not properly handled. It has been known that the plant-derived wastes contain high levels of polysaccharides like celluloses, hemicelluloses, glucans, lignocelluloses, as well as other essential compounds that include phytochemicals, protein, sugar, and fat. Process intensification via increase in raw material consumption, reducing solvent, and exploiting wastes, can cause a substantial change developing economically viable chemical products that are environmentally-friendly. The action from applying valorization techniques on these compounds, most especially in the food wastes, will mitigate the several health and environmental hazards associated with waste pollution, enhance ecosystem sustainability, and promote value addition in generating wealth-from-waste in the agro-food industries. Therefore, this chapter reviewed the recent trends in the application of novel integrated processes/technologies involving agricultural wastes for the production of pharmaceutical products.
