Fig 3 - available from: BMC Urology
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The histopathological examination showed the tumor cells containing intracellular mucin-filled vacuole displacing the hyperchromatic nucleus to one side suggestive of signet ring cell carcinoma
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Background:
Upper tract urothelial carcinoma with pure non-urothelial histology is an exception but variants are present in ~ 25% of cases. Primary upper urinary tract signet -ring cell carcinoma is extremely rare.
Case presentation:
We report the case of a 65-year-old male diagnosed primary upper urinary tract signet-ring cell carcinoma while u...
Context in source publication
Context 1
... 20-Fr Foley catheter was kept as a nephrostomy tube and the catheter balloon was injected with 10ml saline and pulled to compress the nephrostomy tract ( Figure 2). The histopathological examination showed the tumor cells containing intracellular mucin-filled vacuole displacing the hyperchromatic nucleus to one side suggestive of signet ring cell carcinoma (Figure 3). Immunohistochemical examination showed: CK, CK7, CK20, CEA, CDX2 (+), Villin (small +), Vim, GATA3, P53 (-), Ki-67 (about 60% +).Post-operative PET/CT (18F-FDG8.6mCi ...
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Citations
... On the other hand, squamous cell carcinoma contributes to 80%, transitional cell carcinoma to 10% and adenocarcinoma to 10% of UC in the bulbo-membranous urethra [2]. Adenocarcinoma of the urethra arises from the periurethral glands and can be of the following subtypes-enteric, not otherwise specified, mucinous, clear cell and signet ring cell [3].Primary signet ring cell adenocarcinoma of the urinary tract is extremely rare, with only a handful of cases involving the bladder and upper tracts and female urethra [4][5][6][7]. Our case is the first report of signet ring cell adenocarcinoma of the male urethra in the English literature. ...
... Primary signet ring cell carcinoma of the urethra is an extremely rare disease, and therefore, treatment protocols for this malignancy are unclear. The treatment is usually extrapolated from signet ring cell adenocarcinoma occurring in other organs of the genitourinary tract [4,6]. Distal UC can be treated by penile preserving procedures with or without pelvic lymph node dissection [11].Positive surgical margins, lymphovascular invasion and perineural invasion are risk factors for recurrence after penile preserving surgeries [12].Radical cystoprostatectomy with urethrectomy/penectomy and bilateral pelvic lymph node dissection is the surgical treatment of choice in proximal tumours [12]. ...
Malignant tumours of the male urethra are rare and commonly present at an advanced stage. The most common type of urethral cancer is urothelial carcinoma, followed by squamous cell carcinoma. Less than 5% of urethral cancers are adenocarcinoma. We report a young male with signet ring cell carcinoma of the membranous urethra who presented with recurrent lower urinary tract symptoms. Although he was initially treated for a urinary tract infection, the correct diagnosis was made with an appropriate imaging workup. He underwent radical urethrectomy with total pelvic exenteration with bilateral extended pelvic lymph node dissection. Ileal conduit and colostomy were performed as urinary and bowel diversions, respectively. The patient received adjuvant chemotherapy, however, succumbed to COVID-19 8 months after the procedure. This case has been presented to highlight the high index of suspicion required to diagnose this rare malignancy.
... Upper urinary tract carcinomas account for 5-10% of all urinary tract malignancies, and histological variances are observed in roughly quarter of the cases. 1 Of these variances, SRCC is extremely rare, with only a number of reported cases. The vast majority of urinary SRCCs are of lower urinary tract origin or secondary tumors. ...
... Therefore, gastrointestinal endoscopy and colonoscopy to rule out the possibility of a gastrointestinal origin appear to be good clinical practice. 1,3 The clinical significance of serum tumor makers in SRCC has not been established. In advanced gastric cancer including gastric SRCC, CEA, and CA19-9 levels are known to often increase, both of which were normal in our patient. ...
... 9 Interestingly, Ye has also reported a case of upper urinary tract SRCC where these markers were not elevated. 1 Although intriguing, the diagnostic relevance of this result is uncertain. ...
Introduction:
Signet-ring cell carcinoma is an extremely rare histological variant of upper urinary tract carcinoma, associated with poor prognosis.
Case presentation:
We report a case of a 75-year-old female diagnosed with left primary upper urinary tract signet-ring cell carcinoma, initially treated with surgery. Post-surgical development of multifocal metastases was followed by a devastating clinical course. An autopsy confirmed the tumor's primary origin in the upper urinary tract.
Conclusion:
We experienced a case of upper urinary tract signet-ring cell carcinoma, with a rare opportunity to thoroughly confirm its primary site with an autopsy.
