Figure - available from: Disease Markers
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The expression profiles of lncRNAs and mRNAs. (a, b) A heat map showing the expression profiles of differentially expressed (DE) lncRNAs (a) and DE mRNAs (b) in the serum of individuals with A: atrial fibrillation (AF) or without C: control. (c, d) A volcano diagram showing levels of serum lncRNAs (c) and mRNAs (d) in AF and non-AF patients. The green and red bolts represent downregulated and upregulated genes (p≤0.05; fold change≥2), respectively. (e) A pie chart representing DE lncRNA distribution, based on their position on the genome. (f) The qRT-PCR-identified expression of 6 lncRNAs, namely, NR-038435, NR-001587, NR-015407, NR-038455, NR-038894, and NR-131216 in the serum of AF patients and healthy volunteers. Data are presented as mean±standard error, n=17, ∗p<0.05.
Source publication
Objectives:
Long noncoding RNAs (lncRNAs) are closely related to diverse diseases. However, its role in atrial fibrillation (AF) pathogenesis needs further exploration.
Design:
We performed microarray analysis on the serum samples from 70 healthy volunteers and 70 AF patients. This study was aimed at detecting the levels of serum lncRNAs and mRN...
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