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The effects of pyridoxine deficiency and benzene inhalation exposure (0 or 100 ppm) on white blood cell counts, percentages of neutrophils, lymphocytes and eosinophils, hematocrit and hemoglobin. Values are expressed as mean ± SE (n = 10/group). a, b
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Pyridoxine is a co-factor in many enzymatic reactions and impacts of deficiency have been observed in affected populations. A possible modifying effect of pyridoxine deficiency on benzene toxicity was assessed in male B6C3F1 mice fed either a pyridoxine-deficient diet or a control diet. This treatment was combined with benzene inhalation exposure (...
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... lower WBC number than in benzene-untreated PD-0 mice (by 45 %, p < 0.05). Benzene inhalation exposure in the CD-100 group resulted in a significant decrease in WBC numbers compared to the CD-0 controls (by 48 %, p < 0.05). The greatest reduction in WBC numbers (by 61 %, p < 0.001) was observed in the PD-100 group compared to CD-0 controls (Fig. 1A). However, there was not a statistically significant difference in WBC numbers between the two-benzene inhalation-exposed groups (numbers in PD-100 mice were 27 % lower than those in CD-100 mice; p = ...
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... was observed in the pyridoxine-deficient mice compared to their respective diet-matched controls (PD-100 vs. PD-0, 3.0-fold higher, p < 0.001). Interestingly, the combination of pyridoxine deficiency and benzene exposure in the PD-100 mice yielded the greatest effect on neutrophil counts (3.8-fold higher, p < 0.001) compared to the CD-0 controls (Fig. 1B). The difference between the two benzene inhalation-exposed groups (CD-100 vs. PD-100) was statistically significant (p < ...
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... pyridoxine deficiency (PD-0) or benzene inhalation exposure (CD-100) alone significantly reduced lymphocyte values compared to the CD-0 controls (by 6 % and 22 %, respectively, p < 0.05, Fig. 1C). However, benzene inhalation exposure of pyridoxine deficient mice (PD-100) yielded the greatest effect (41 % lower than in the CD-0 controls, p < ...
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... The PD-100 mice had significantly lower numbers of eosinophils (by 63 %) and basophils (by 32 %) compared to the CD-0 controls (p < 0.05). The differences in the number of eosinophils between the PD-100 and PD-0 groups (p = 0.094), and between the two benzene-exposed groups (CD-100 vs. PD-100, p = 0.568), were not statistically significant (Fig. 1D). A significant difference in monocyte values was observed only in PD-100 mice compared to benzeneunexposed CD-0 controls (p < ...
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Background
The goal of blood transfusion is to provide a safe, sufficient, and timely supply of blood components to the recipients by ensuring that donation is safe and no harm to the recipient. So the current study was aimed to assess blood transfusion utilization and its outcome in patients at Yekatit-12 Hospital, Addis Ababa, Ethiopia.
Methods...
