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The effect of ligand and their complexes on the growth of bacteria.

The effect of ligand and their complexes on the growth of bacteria.

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Figure 1. Suggested structure of the Co(II) and Mn(II) complexes. 
Figure 2. The effect of ligand and their complexes on the growth of...
Study of the Cytotoxicity Effect of New Co(II) and Mn(II) Complexes of Flavon on Cancer ( Cell Line RD) and Antimicrobial Activity
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  • Mar 2017
A new series of Co(II) and Mn(II) complexes with the Flavone ligand were studied on the growth of Rhabdomyo sarcomas (RD) cell Line in human by using in vitro system and compared with anticancer drug cisplatin (cis-pt) as appositive control. The cancer cells were treated with different concentration and cis-pt after 72 hr. exposure time. The cytoto...
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Synthesis, crystallographic studies, electrochemical and in vitro cytotoxicity properties of two Mn‌(II) and U(IV) complexes containing dipicolinic acid and 4-dimethylaminopyridine
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  • Feb 2020
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Two new coordination complexes, [pydcH2][Mn2(pydc)2(H2O)6] (1) and [dmapH2][UO2(pydc)2] (2) were obtained from a compound containing dipicolinic acid and 4-dimethylaminopyridine.The complexes were characterized by X-ray crystallography. Electrochemical behavior of the compounds was investigated by cyclic voltammograms. Redox couples were observed at E0ˊ 1.625 and –0.159 V for (1) and (2) respectively, versus Ag/AgCl, under argon. After aeration, stronger interaction tendency with oxygen was exhibited for complex (1) compared to (2), within 5 minutes. In the next section, toxicity of each of three compounds were assayed using oxaliplatin as a standard, under MTT method, against MCF7 (a human breast cancer), HeLa (a human cervix epithelioid carcinoma) and KB (a human oral epithelial carcinoma) cell lines. Complex (1) with E⁰ˊ of about ten times (2) proved further cytotoxic potential on all three tested cancerous cell line compared to (2). The highest inhibition potential was exhibited on MCF7 cell line (IC50=1.00 μM, Viability inhibition= 81.19%) for (1). Determination of mitochondrial membrane potential (MMP) and reactive oxygen species (ROS) in treated MCF7 cells with (1) confirmed a clear decrease in MMP and sharp increases in ROS generation in this cell line.
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